IP Library › Granted Patent US 10,376,514
Granted Patent B2
US 10,376,514 · App. 16/164,726 · Granted Aug 13, 2019

Therapeutic thiophene-, furan-, and pyridine-fused azolopyrimidin-5-(6H)-ones

Inventors: Bryan Branstetter (Carlsbad, CA); James Breitenbucher (Escondido, CA); Brian Dyck (San Diego, CA); Laurent Gomez (San Diego, CA); Andrew Richard Hudson (San Diego, CA); Tami Jo Marrone (Carlsbad, CA); Marco Peters (San Diego, CA); Troy Vickers (San Diego, CA); Michael I. Weinhouse (Escondido, CA)
Assignee: Dart Neuroscience (Cayman) Ltd.
A61K31/519A61K31/5377A61K31/5386A61K31/541A61K31/55A61K31/551A61K31/553A61P9/00A61P25/00C07D471/14C07D487/14C07D491/107C07D491/147C07D491/22C07D495/12C07D495/14C07D495/22C07D498/08C07D519/00
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Quick Facts
Patent No.
US 10,376,514
App. No.
16/164,726
Granted
Aug 13, 2019
Kind
B2
Abstract

Described herein are compounds of Formula I and Formula II, methods of their synthesis, compositions comprising the compounds, and use of the compounds and compositions in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders.

Claims (20)

1. A compound, or a pharmaceutically acceptable salt thereof, having the structure:

2. The compound of claim 1 , wherein the compound is

3. The compound of claim 1 , wherein the compound is

4. The compound of claim 1 , wherein the compound is

5. The compound of claim 1 , wherein the compound is

6. The compound of claim 1 , wherein the compound is

7. The compound of claim 1 , wherein the compound is

8. A compound, or a pharmaceutically acceptable salt thereof, having the structure:

9. The compound of claim 8 , wherein the compound is

10. The compound of claim 8 , wherein the compound is

11. The compound of claim 8 , wherein the compound is

12. The compound of claim 8 , wherein the compound is

13. The compound of claim 8 , wherein the compound is

14. The compound of claim 8 , wherein the compound is

15. A compound, or a pharmaceutically acceptable salt thereof, having the structure:

16. The compound of claim 15 , wherein the compound is

17. The compound of claim 15 , wherein the compound is

18. The compound of claim 15 , wherein the compound is

19. The compound of claim 15 , wherein the compound is

20. The compound of claim 15 , wherein the compound is

Assignments (1)
MERGER Recorded Dec 2, 2021
From: DART NEUROSCIENCE (CAYMAN) LTD.
To: DART NEUROSCIENCE LLC
Reel/Frame 058275/0272 →
Continuity (5)
Continuation 15394058 · Dec 29, 2016
Continuation 14853856 · Sep 14, 2015
Division 13920974 · Jun 18, 2013
Provisional Application 61661091 · Jun 18, 2012
Related Publication 20190046535A1 · Feb 14, 2019