COMPOSITION AND METHOD FOR THE DIAGNOSIS AND TREATMENT OF DISEASES ASSOCIATED WITH NEURITE DEGENERATION
Provided herein are antibodies and methods of using the antibodies to treat and diagnose neurite degenerative diseases and disorders.
1 - 47 . (canceled)
48 . A nucleic acid comprising a nucleotide sequence encoding an anti-Repulsive Guidance Molecule a (RGMa) antibody having a heavy chain comprising the amino acid sequence of SEQ ID NO:147 and a light chain comprising the amino acid sequence of SEQ ID No: 146.
49 . A vector comprising the isolated nucleic acid of claim 48 .
50 . The vector of claim 49 , wherein the vector further comprises:
CMV enhancer/AdMLP promoter regulatory elements; and
a DHFR gene,
wherein the heavy chain and light chain are each operatively linked to the CMV enhancer/AdMLP promoter regulatory elements.
51 . A host cell transformed with the vector of claim 50 .
52 . The host cell of claim 51 , wherein the host cell is a eukaryotic cell.
53 . The host cell of claim 52 , wherein the eukaryotic cell is a mammalian host cell.
54 . A method of producing a monoclonal anti-RGMa antibody comprising:
(a) culturing the eukaryotic host cell of claim 53 ; and
(b) recovering the anti-RGMa antibody.