Pinch to open sample collection device
A blood sample collection and/or storage device includes a two-piece housing that encompasses a port at which a fingertip blood sample is collected. After the sample is taken, the two-piece housing is moved to a closed position to protect the sample for storage and optionally process the sample within the housing. The housing may also be opened to access the stored sample for further processing.
1. An apparatus for collecting a biological sample, the apparatus comprising:
a housing configurable from an open position to a closed position;
a sample collection port configured to collect the biological sample when the housing is in the open position;
one or more fluid pathways configured to draw in the biological sample from the collection port;
a membrane, disposed within the housing, wherein the membrane comprises a preservative,
a structural member disposed within the housing and configured to hold the membrane within the housing;
a mechanical actuator, configured to dispense the biological sample from the one or more fluid pathways onto the membrane when the housing is moved from the open position to the closed position; and
a desiccant;
wherein a portion of said membrane is configured to separate cellular material from the biological sample when the biological sample is introduced onto the membrane, wherein the housing is further configured to allow the fluid pathways to be viewed when the housing is in the open position;
wherein the one or more fluid pathways comprise a capillary tube,
wherein the apparatus further comprises a reagent (i) coated on an inner surface of the capillary tube or (ii) comprised in the membrane,
wherein the mechanical actuator comprises one or more plungers which are configured to be inserted into the one or more fluid pathways, and
wherein the sample collection port is inaccessible when the housing is in the closed position.
2. The apparatus of claim 1 , wherein the housing comprises two or more pieces, and wherein the structural member contains the sample collection port, supports the two or more pieces, allows the two or more pieces to move relative to each other along a length of the structural member from the open position to the closed position.
3. The apparatus of claim 1 , further comprising: an area in or adjacent to the sample collection port having a hydrophobic property.
4. The apparatus of claim 1 , wherein the mechanical actuator comprises two or more plungers, and wherein two or more of the two or more plungers are activated in parallel upon closing the housing.
5. The apparatus of claim 1 wherein the preservative comprises a sugar.
6. The apparatus of claim 1 , further comprising: a barcode or other identifying indicia.
7. The apparatus of claim 1 further comprising: a preservative or stabilizing reagent, disposed within the fluid pathways.
8. The apparatus of claim 1 further comprising: one or more capillary tubes positioned between the sample collection port and the membrane, the one or more capillary tubes configured to dispense the portion of the biological sample from the collection port onto the membrane upon actuation of the mechanical actuator.
9. The apparatus of claim 1 further comprising: an area in or adjacent to the sample port having a hydrophobic property.
10. The apparatus of claim 1 further comprising: a dried reagent configured to be placed in a path of the biological sample as it is dispensed to the membrane.
11. The apparatus of claim 1 further comprising: a locking mechanism, configured to lock the housing as it is moved from the first to the second position.
12. The apparatus of claim 1 wherein a portion of the housing is configured to allow a volume of the sample within the one or more fluid pathways to be viewed when the housing is in the open position.
13. The apparatus of claim 1 wherein the desiccant is contained within the housing.
14. The apparatus of claim 1 , wherein the housing defines an isolated internal air space above the membrane, and wherein the membrane and the desiccant are in contact with the isolated internal air space.
15. The apparatus of claim 14 , wherein the housing defines an isolated internal air space above the membrane when the housing is in the closed position, and wherein the membrane and the desiccant are in contact with the isolated internal air space when the housing is in the closed position.
16. The apparatus of claim 1 , further comprising a locking mechanism configured to prevent the housing from being reopened after it is in the closed position.
17. The apparatus of claim 16 , wherein the housing further comprises an opening in an external surface of the housing, and wherein locking mechanism comprises tines configured to be inserted into the opening when the housing is in the closed position.
18. The apparatus of claim 1 , further comprising a capillary support element contacting the one or more fluid pathways, wherein the one or more fluid pathways comprise capillary tubes, wherein the capillary support element aligns the one or more plungers with the capillary tubes for actuation when the housing is moved from the open position to the closed position.