Goggle imaging systems and methods
A goggle system is provided. The goggle system includes a computing device, a goggle device configured to be worn by a user and including a detector configured to simultaneously acquire image data of a subject in a first image mode and a second image mode, at least one eye assembly configured to display at least one of an image in the first image mode, an image in the second image mode, and a hybrid image including pixels of image data from the first image mode and pixels of image data from the second image mode, and a communications module configured to transmit acquired image data from the goggle device to the computing device.
1. A goggle device configured to be worn by a user and comprising:
a detector configured to simultaneously acquire image data from a plurality of fluorescent molecules, a plurality of luminescent materials, or a combination thereof in a state of excitation caused by a fluorescence excitation light source, and from visible light illuminated by a white light source; and
at least one eye assembly configured to display pixels of the acquired image data in real-time.
2. The goggle device according to claim 1 , wherein said white light source comprises a plurality of white light emitting diodes.
3. The goggle device according to claim 1 , wherein the fluorescence excitation light source provides a view of 0.3 meters in diameter at 1 meter from a subject.
4. The goggle device according to claim 1 , further comprising a second fluorescence excitation light source.
5. The goggle device according to claim 1 , wherein the at least one eye assembly is further configured to display an image selectable from a first image mode associated with the image data from the plurality of fluorescent molecules, the plurality of luminescent materials, or a combination thereof, and a second image mode associated with the image data from the visible light.
6. The goggle device according to claim 5 , wherein the first image mode is selected from the group consisting of at least one of a far infrared image mode, a near infrared image mode, a photoacoustic image mode, an interference image mode, an optical coherence tomography image mode, a diffusion optical tomography image mode, a polarization image mode, an ultrasound image mode, a nuclear image mode, a computed tomography image mode, a gamma image mode, and an X-ray image mode.
7. The goggle device according to claim 1 , wherein the detector includes a plurality of first image mode detector elements and a plurality of second image mode detector elements, and wherein at least one of the plurality of first image mode detector elements and the plurality of second image mode detector elements comprises a plurality of alternating layers containing p-n junctions.
8. The goggle device according to claim 1 , wherein the detector includes a plurality of first image mode detector elements and a plurality of second image mode detector elements, and wherein the first and second image mode detector elements are arranged in a checkerboard pattern.
9. The goggle device according to claim 1 , further comprising a switch configured to switch between different imaging modes displayed in real-time on said at least one eye assembly.
10. A goggle system comprising:
a computing device;
a goggle device configured to be worn by a user;
a detector configured to simultaneously acquire image data from a plurality of fluorescent molecules, a plurality of luminescent materials, or a combination thereof in a state of excitation caused by a fluorescence excitation light source, and from visible light illuminated by a white light source; and
at least one eye assembly configured to display pixels of the acquired image data in real-time.
11. The goggle system according to claim 10 , wherein the white light source comprises a plurality of light emitting diodes.
12. The goggle system according to claim 10 , wherein the fluorescence excitation light source providing a view of 0.3 meters in diameter at 1 meter from a subject.
13. The goggle system according to claim 10 , further comprising a second fluorescence excitation light source detached from the goggle device.
14. The goggle system according to claim 10 , wherein the at least one eye assembly is further configured to display an image selectable from a first image mode associated with the image data from the plurality of fluorescent molecules, the plurality of luminescent materials, or the combination thereof, and a second image mode associated with the image data from the visible light.
15. The goggle system according to claim 14 , wherein the first image mode is selected from the group consisting of at least one of a far infrared image mode, a near infrared image mode, a photoacoustic image mode, an interference image mode, an optical coherence tomography image mode, a diffusion optical tomography image mode, a polarization image mode, an ultrasound image mode, a nuclear image mode, a computed tomography image mode, a gamma image mode, and an X-ray image mode.
16. The goggle system according to claim 10 , wherein the detector includes a plurality of first image mode detector elements and a plurality of second image mode detector elements, and wherein at least one of the plurality of first image mode detector elements and the plurality of second image mode detector elements comprises a plurality of alternating layers containing p-n junctions.
17. The goggle system according to claim 10 , wherein the detector includes a plurality of first image mode detector elements and a plurality of second image mode detector elements, and wherein the first and second image mode detector elements are arranged in a checkerboard pattern.
18. The goggle system according to claim 10 , further comprising a switch configured to switch between different imaging modes displayed in real-time on said at least one eye assembly.
19. The goggle system according to claim 10 , wherein said at least one eye assembly comprises:
a left eye assembly configured to display an image in real-time to a left eye of the user; and
a right eye assembly configured to display an image in real-time to a right eye of the user.
20. A method for detection using a goggle device, the method comprising:
acquiring image data with a goggle device configured to be worn by a user, the image data being acquired from a plurality of fluorescent molecules, a plurality of luminescent materials, or a combination thereof in a state of excitation caused by a fluorescence excitation light source, and from visible light illuminated by a white light source; and
displaying pixels of the acquired image data from the subject in real-time on at least one eye assembly of the goggle device.
21. The goggle system according to claim 10 , further comprising an endoscope.
22. The method of claim 20 , further comprising administering the plurality of fluorescent molecules, the plurality of luminescent materials, or the combination thereof to a subject.
23. The goggle device of claim 1 , wherein the plurality of fluorescent molecules comprises at least one selected from the group consisting of fluorescent dyes and fluorescent molecular probes.
24. The goggle device of claim 1 , wherein the plurality of luminescent materials is localized in a tissue of interest, and the fluorescence emitted by the excited plurality of luminescent materials is absorbed by the plurality of fluorescent molecules.
25. The goggle device of claim 1 , wherein the plurality of fluorescent molecules, the plurality of luminescent materials, or the combination thereof comprises a fluorescent molecular probe chosen from LS-301.
26. The goggle device of claim 1 , wherein the plurality of luminescent materials comprises at least one selected from the group consisting of nanoparticles and quantum dots.