Anti-CD37 immunoconjugate and anti-CD20 antibody combinations
Methods of administering immunoconjugates that bind to CD37 (e.g., IMGN529) in combination with antibodies that bind to CD20 are provided. The methods comprise administering an anti-CD37 immunoconjugate (e.g., IMGN529) and an anti-CD20 antibody to a person in need thereof, for example, a cancer patient.
1. A method for treating a human patient having a B-cell cancer comprising administering to said patient in need thereof (i) an immunoconjugate that binds to CD37 comprising a DM1 maytansinoid, an SMCC linker, and an antibody that binds to CD37 comprising the heavy chain sequence set forth in SEQ ID NO:18 and the light chain sequence set forth in SEQ ID NO: 21; and (ii) rituximab, wherein said immunoconjugate that binds to CD37 is administered at a dose of 0.7 mg/kg once every three weeks and wherein the rituximab is administered at a dose of about 375 mg/m2 on week 1, day 1 of a three week schedule.
2. The method of claim 1 , wherein the immunoconjugate that binds to CD37 and the rituximab produce a synergistic effect, with a Synergy Score of at least 4 in vitro.
3. The method of claim 1 , wherein the immunoconjugate that binds to CD37 and the rituximab have a combination index value of less than 0.5.
4. The method of claim 1 , wherein the cancer is leukemia or lymphoma.
5. The method of claim 1 , wherein the cancer is selected from the group consisting of NHL, precursor B-cell lymphoblastic leukemia/lymphoma, B-cell chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL), B-cell prolymphocytic leukemia, lymphoplasmacytic lymphoma, mantle cell lymphoma (MCL), follicular lymphoma (FL), cutaneous follicle center lymphoma, marginal zone B-cell lymphoma, hairy cell leukemia, diffuse large B-cell lymphoma (DLBCL), Burkitt's lymphoma, plasmacytoma, plasma cell myeloma, post-transplant lymphoproliferative disorder, Waldenstrom's macroglobulinemia, acute lymphoblastic leukemia (ALL), and anaplastic large-cell lymphoma (ALCL).
6. The method of claim 1 , wherein the cancer overexpresses MYC and/or BCL2.
7. The method of claim 1 , wherein the immunoconjugate that binds to CD37 and the rituximab are administered intravenously.
8. The method of claim 1 , further comprising administering a corticosteroid to the patient.
9. The method of claim 1 , further comprising administering a growth factor to the patient.
10. The method of claim 1 , wherein the human patient has relapsed diffuse large B-cell lymphoma (DLBCL).