Cartridge portion of transdermal drug delivery apparatus and methods
A cartridge, which may be suitable for use as a portion of a transdermal drug delivery apparatus, may include a body at least partially defining an interior for containing fluid for being delivered by the transdermal drug delivery apparatus. The body may also at least partially define first and second openings to the interior of the body, wherein the first and second openings are respectively proximate opposite first and second ends of the body. The cartridge may also include a self-sealing member at least partially closing the first opening, and a movable member at least partially closing the second opening, wherein at least a portion of the movable member is for being urged into the interior of the body for increasing pressure within the interior of the body.
1. A method of at least partially assembling a transdermal drug delivery apparatus, the method comprising:
moving a cartridge into a receptacle and toward a microneedle assembly, the microneedle assembly including a support plate and a plurality of microneedles extending from the support plate, wherein
the microneedle assembly is mounted to the receptacle, and
the cartridge contains a fluid for being supplied to the microneedle assembly; and
the movement of the cartridge toward the microneedle assembly being arrested in response to engagement of a connector, wherein
the engagement of the connector comprises a connected state, wherein
in the connected state, the connector is configured to temporarily restrict the movement of the cartridge toward the microneedle assembly so that the cartridge is spaced apart from and out of fluid communication with the microneedle assembly, wherein in the connected state, tips of the plurality of microneedles are configured to protrude outwardly through a lower opening of the receptacle, wherein
the connector includes a first connector part and a second connector part,
the receptacle includes the first connector part, and
the cartridge includes the second connector part;
wherein the first and second connector parts are releasably connectable to facilitate transitioning from the connected state to an unconnected state in response to relative movement between the receptacle and the cartridge caused by a force exceeding a predetermined amount; and
wherein a controller is connected to the cartridge by way of at least one snap-fit connector, wherein the controller is configured to urge the cartridge from the connected state to the unconnected state.
2. The method according to claim 1 , wherein:
the connector comprises an additional snap-fit connector; and
wherein the first and second connector parts of the connector comprise snap-fit connector parts.
3. The method according to claim 1 , further comprising mounting a pushbutton to the cartridge prior to the moving of the cartridge into the receptacle, wherein a portion of a housing of the controller is the pushbutton.
4. A drug delivery apparatus comprising:
a receptacle comprising a first connector part;
a microneedle assembly mounted to the receptacle, the microneedle assembly including a support plate and a plurality of microneedles extending from the support plate; and
a cartridge containing a fluid for being supplied to the microneedle assembly and comprising a second connector part;
wherein the first and second connector parts are releasably connectable to facilitate transitioning from a connected state to an unconnected state in response to relative movement between the receptacle and the cartridge caused by a force exceeding a predetermined amount; and
wherein a controller is connected to the cartridge by way of at least one snap-fit connector, wherein the controller is configured to urge the cartridge from the connected state to the unconnected state;
the cartridge being positionable within the receptacle such that the second connector part engages the first connector part to inhibit movement of the cartridge toward the microneedle assembly, wherein when the first connector part is engaged with the second connector part, (i) the cartridge is spaced apart from and out of fluid communication with the microneedle assembly, and (ii) tips of the plurality of microneedles are configured to protrude outwardly through a lower opening of the receptacle.
5. The drug delivery apparatus according to claim 4 , wherein the first and second connector parts comprise snap-fit connector parts.
6. The drug delivery apparatus according to claim 4 , wherein the cartridge is mounted between the controller and the receptacle.
7. The drug delivery apparatus according to claim 4 , wherein the cartridge further comprises a body at least partially defining an interior for containing the fluid, and first and second openings to the interior of the body, wherein the first and second openings are respectively defined by opposite first and second ends of the body.
8. The drug delivery apparatus according to claim 7 , wherein the cartridge further comprises a self-sealing member at least partially closing the first opening and a movable member at least partially closing the second opening, wherein at least a portion of the movable member is configured for being urged into the interior of the body for increasing pressure within the interior of the body.
9. The drug delivery apparatus according to claim 8 , wherein the self-sealing member comprises a self-sealing septum.
10. The drug delivery apparatus according to claim 8 , wherein the movable member comprises a deformable membrane, at least a portion of the deformable membrane configured for being urged into the interior of the body for increasing pressure within the interior of the body.
11. The drug delivery apparatus according to claim 4 , wherein the cartridge further comprises an outer wall, wherein the first connector part is a latch extending radially inwardly towards the outer wall of the cartridge, wherein the second connector part is an annular groove defined in the outer wall of the cartridge.
12. A drug delivery apparatus comprising:
a receptacle;
a microneedle assembly mounted to the receptacle, the microneedle assembly including a support plate and a plurality of microneedles extending from the support plate; and
a cartridge containing a fluid for being supplied to the microneedle assembly, the cartridge being positionable within the receptacle such that movement of the cartridge toward the microneedle assembly is arrested in response to engagement of a connector, wherein the engagement of the connector comprises a connected state, wherein the connector is configured to temporarily restrict movement of the cartridge toward the microneedle assembly so that the cartridge is spaced apart from and out of fluid communication with the microneedle assembly in the connected state, wherein in the connected state, tips of the plurality of microneedles are configured to protrude outwardly through a lower opening of the receptacle, wherein the connector comprises a first connector part and a second connector part, wherein the first connector part is located on the receptacle and the second connector part is located on the cartridge,
wherein the first and second connector parts are releasably connectable to facilitate transitioning from the connected state to an unconnected state in response to relative movement between the receptacle and the cartridge caused by a force exceeding a predetermined amount; and
wherein a controller is connected to the cartridge by way of at least one snap-fit connector, wherein the controller is configured to urge the cartridge from the connected state to the unconnected state.
13. The drug delivery apparatus according to claim 12 , wherein the cartridge further comprises a body at least partially defining an interior for containing the fluid, and first and second openings to the interior of the body, wherein the first and second openings are respectively defined by opposite first and second ends of the body.
14. The drug delivery apparatus according to claim 13 , wherein the cartridge further comprises a self-sealing member at least partially closing the first opening and a movable member at least partially closing the second opening, wherein at least a portion of the movable member is configured for being urged into the interior of the body for increasing pressure within the interior of the body.