Pharmaceutical composition comprising IL-34 and a mTOR inhibitor
The invention relates to an isolated interleukin-34 (IL-34) polypeptide for use in preventing or treating graft rejection, autoimmune disease, unwanted immune response against therapeutic proteins and allergy. The invention also provides an in vitro method for determining whether a patient is at risk of transplant rejection, autoimmune diseases, unwanted immune response against therapeutic proteins or allergies, comprising a step of determining the expression level of IL-34 in a biological sample obtained from said patient, wherein the presence of IL-34 is indicative of a reduced risk of transplant rejection, autoimmune diseases, unwanted immune response against therapeutic proteins or allergies.
1. A pharmaceutical composition comprising, in combination, a therapeutically effective amount of an isolated interleukin-34 (IL-34) polypeptide and a suboptimal dose of a mammalian target of rapamycin (mTOR) inhibitor, wherein the suboptimal dose is a dose, which, by itself, does not produce a statistically significant therapeutic effect.
2. The pharmaceutical composition according to claim 1 , wherein the mTOR inhibitor is rapamycin (sirolimus).
3. The pharmaceutical composition of claim 1 , wherein the IL34 polypeptide has a sequence comprising the sequence as set forth in SEQ ID NO: 1.
4. A method of treating autoimmune diseases comprising the step of administering to a patient in need thereof a therapeutically effective amount of the pharmaceutical composition of claim 1 .