Methods of reducing small, dense LDL particles
The present invention provides methods for increasing LDL particle size.
1. A method of changing the LDL particle size pattern in a human having LDL particle size pattern I or B, from pattern I to pattern A, or from pattern B to pattern I or A, comprising:
(i) the identification of the human as having LDL particle size pattern I or B; and
(ii) the administration to the human of a therapeutically effective amount of a compound of the formula
or a salt thereof;
thereby changing the LDL particle size pattern of the human from pattern I to pattern A, or from pattern B to pattern I or A.
2. The method of claim 1 , where the human is identified as having an LDL particle size pattern B prior to administration of the compound.
3. The method of claim 2 , where the human is identified as having an LDL particle size pattern I after administration of the compound.
4. The method of claim 1 , where the human has diabetes.
5. The method of claim 1 , where the human is insulin resistant.
6. The method of claim 1 , where the human has atherosclerosis.
7. The method of claim 1 , where the human has metabolic syndrome.
8. The method of claim 1 , where the human has dyslipidemia.
9. The method of claim 1 , further comprising administration to the human of a statin.
10. The method of claim 9 , where the statin is atorvastatin.