Inverting thrombectomy apparatuses having enhanced tracking
View Patent ↗Mechanical thrombectomy apparatuses, and particularly knitted rolling tube mechanical thrombectomy apparatuses configured to have improved tracking for delivery through tortious vessels are described herein. Also described herein are methods of removing clots using a mechanical thrombectomy apparatuses in which the clot is larger than the tractor portion of the mechanical thrombectomy apparatus.
1. A method of removing a clot from a vessel, the method comprising:
advancing an inverting tube apparatus through a vessel until a distal end of the inverting tube apparatus is proximate to a clot, wherein the inverting tube apparatus comprises an intermediate catheter, an inversion support catheter within a lumen of the intermediate catheter, a puller within a lumen of the inversion support catheter, and a flexible tube having a first end coupled at a distal end region of the puller and a second end that is free to move over an outer surface of the inversion support catheter, wherein the flexible tube extends proximally between the intermediate catheter and the inversion support catheter;
pulling the puller proximally to roll the flexible tube over a distal end of the inversion support catheter so that the flexible tube inverts over a distal end of the inversion support catheter, captures the clot, and pulls the clot proximally into the inversion support catheter, wherein the second end reaches the distal end of the inversion support catheter while a portion of the clot extends distally from the inversion support catheter; and
withdrawing, after the second end reaches the distal end of the inversion support catheter, the inversion support catheter and puller with the clot attached proximally into the intermediate catheter until the entire clot is within the intermediate catheter.
2. The method of claim 1 , further comprising applying suction through the inverting tube apparatus when withdrawing the inversion support catheter and puller with the clot attached proximally into the intermediate catheter.
3. The method of claim 1 , wherein the second end of the flexible tube comprises a cuff that is less flexible that a region of the flexible tube adjacent to the cuff.
4. The method of claim 1 , wherein the second end of the flexible tube comprises a cuff having longitudinal slits along its length.
5. The method of claim 3 , wherein the cuff comprises a polymeric material.
6. The method of claim 3 , further comprising limiting the puller to stop the puller from moving proximally when or before the cuff reaches the distal end of the inversion support catheter.
7. The method of claim 3 , further comprising moving the intermediate catheter distally past the cuff to invert the cuff over the distal end of the inversion support catheter.
8. A method of removing a clot from a vessel, the method comprising:
advancing an inverting tube apparatus through a vessel until a distal end of the inverting tube apparatus is proximate to a clot, wherein the inverting tube apparatus comprises an intermediate catheter, an inversion support catheter within a lumen of the intermediate catheter, a puller within a lumen of the inversion support catheter, and a flexible tube having a first end coupled at a distal end region of the puller and a second end comprising a cuff that is less flexible that a region of the flexible tube adjacent to the cuff, wherein the flexible tube extends proximally between the intermediate catheter and the inversion support catheter;
pulling the puller proximally to roll the flexible tube over a distal end of the inversion support catheter so that the flexible tube inverts over a distal end of the inversion support catheter, captures the clot, and pulls the clot proximally into the inversion support catheter;
stopping pulling the puller from moving proximally when or before the cuff reaches the distal end of the inversion support catheter;
moving the intermediate catheter distally past the cuff to invert the cuff over the distal end of the inversion support catheter; and
withdrawing the inversion support catheter and puller with the clot attached proximally into the intermediate catheter.
9. The method of claim 8 , wherein the cuff comprises one or more slits along its length extending in a proximal-to-distal direction.
10. The method of claim 8 , wherein the cuff comprises a polymeric material.
11. A method of removing a clot from a vessel having an inner diameter (ID), the method comprising:
advancing an inverting tube apparatus through the vessel until a distal end of the inverting tube apparatus is proximate to a clot, wherein the inverting tube apparatus comprises an intermediate catheter, an inversion support catheter within a lumen of the intermediate catheter, a puller within a lumen of the support catheter, and a knitted tube having a first end coupled at a distal end region of the puller and a second end, wherein the knitted tube extends between the intermediate catheter and the inversion support catheter;
further wherein the knitted tube comprises a filament knitted to form a plurality of interlocking loop stitches, wherein each loop stitch has a stitch length that is between the difference of 25% of the ID and one half the outer diameter (OD) of the inversion support catheter and 65% of the ID and one half of the OD of the inversion support catheter;
pulling the puller proximally to roll the knitted tube over the distal end of the inversion support catheter so that the knitted tube inverts over a distal end of the inversion support catheter driving the loop stitches outward, captures the clot, and pulls the clot proximally into the inversion support catheter.
12. The method of claim 11 , wherein the knitted tube extends over the inversion support catheter with an inner diameter that is within 20% of the OD the inversion support catheter.
13. The method of claim 11 , wherein the second end of the knitted tube comprises a cuff that is less flexible that a region of the knitted tube adjacent to the cuff.
14. The method of claim 11 , wherein each loop stitch has a stitch length that is between the difference of 30% of the ID and one half the OD of the inversion support catheter and 60% of the ID and one half of the OD of the inversion support catheter.
15. The method of claim 11 , wherein each loop stitch has a stitch length that is between the difference of 35% of the ID and one half the OD of the inversion support catheter and 50% of the ID and one half of the OD of the inversion support catheter.
16. The method of claim 11 , wherein each loop stitch has a stitch length that is between the difference of 40% of the ID and one half the OD of the inversion support catheter and 45% of the ID and one half of the OD of the inversion support catheter.
17. The method of claim 11 , wherein each loop stitch has a stitch length that is between the difference of 25% of the ID and one half the OD of the inversion support catheter and 45% of the ID and one half of the OD of the inversion support catheter.