Inverting thrombectomy apparatuses having enhanced tracking
View Patent ↗Mechanical thrombectomy apparatuses, and particularly knitted rolling tube mechanical thrombectomy apparatuses configured to have improved tracking for delivery through tortious vessels are described herein. Also described herein are methods of removing clots using a mechanical thrombectomy apparatuses in which the clot is larger than the tractor portion of the mechanical thrombectomy apparatus.
1. An inverting tube apparatus for removing a clot from a vessel, the apparatus comprising:
an inversion support catheter;
a puller within a lumen of the inversion support catheter; and
a flexible tube extending over a distal end of the inversion support catheter, the flexile tube having a first end coupled at a distal end region of the puller and a second end comprising a cuff that is less flexible than a region of the flexible tube adjacent to the cuff, wherein the flexible tube is configured to be pulled proximally into the inversion support catheter by pulling the puller proximally so that the flexible tube rolls and inverts over a distal end of the inversion support catheter.
2. The apparatus of claim 1 , wherein the cuff comprises one or more slits along its length extending in a proximal-to-distal direction.
3. The apparatus of claim 1 , wherein the cuff comprises a polymeric material.
4. The apparatus of claim 1 , further comprising a cuff retainer configured to prevent the cuff from extending over the distal end of the inversion support catheter.
5. The apparatus of claim 4 , wherein the cuff retainer comprises one or more filaments coupling the cuff to the inversion support catheter.
6. The apparatus of claim 4 , wherein the cuff retainer comprises a mechanical stop on the inversion support catheter.
7. The apparatus of claim 4 , wherein the cuff retainer comprises one or more filaments connecting the cuff to the puller through a lateral opening in the inversion support catheter.
8. The apparatus of claim 4 , wherein a proximal-facing end of the cuff is tapered.
9. The apparatus of claim 4 , wherein a proximal-facing end of the cuff comprises a low-profile scaffolding extending at least partially around the perimeter of the cuff.
10. The apparatus of claim 1 , further comprising a first proximal port configured to couple with a vacuum source to apply vacuum through the puller.
11. The apparatus of claim 10 , further comprising a second proximal port configured to couple with a vacuum source to apply vacuum between the intermediate catheter and the inversion support catheter.
12. The apparatus of claim 1 , wherein the intermediate catheter is configured to push the cuff over the distal end of the inversion support catheter when the intermediate catheter is advanced distally past the cuff.
13. The apparatus of claim 1 , wherein the flexible tube comprises a knit.
14. The apparatus of claim 1 , wherein the cuff is radiopaque.
15. An inverting tube apparatus for removing a clot from a vessel, the apparatus comprising:
an inversion support catheter;
a puller within a lumen of the inversion support catheter; and
a flexible tube extending over a distal end of the inversion support catheter, the flexile tube having a first end coupled at a distal end region of the puller and a second end comprising a cuff that is less flexible than a region of the flexible tube adjacent to the cuff, wherein the flexible tube is configured to be pulled proximally into the inversion support catheter by pulling the puller proximally so that the flexible tube rolls and inverts over a distal end of the inversion support catheter, and wherein the cuff is tapered at a proximal facing end.
16. An inverting mechanical thrombectomy apparatus for removing a clot from a vessel configured to be delivered through a tortious anatomy, the apparatus comprising:
an inversion support catheter extending distally, the inversion support catheter having a distal end and a distal end opening, the inversion support catheter comprising a plurality of slots or cut-out regions along its length to enhance flexibility while maintaining column strength such that the inversion support catheter is able to withstand at least about 500 g of compressive force;
a puller extending distally within the inversion support catheter; and
a flexible tube extending proximally from a distal end region of the puller,
wherein the flexible tube comprises a knitted material that is held in compression along an outside region of the inversion support catheter and inverts over the distal end opening of the inversion support catheter and couples to the puller, and
wherein the flexible tube is configured such that pulling the puller proximally causes the flexible tube to roll from the outside region of the inversion support catheter, over the distal end opening and invert into the inversion support catheter.