Method of enhancing absorption of ingested medicaments for treatment of an an ailment of the GI tract

1. A method of using a vibrating gastrointestinal capsule in coordination with an ingestible medicament for treatment of an ailment of the gastrointestinal (GI) tract, the method comprising:

(a) providing the vibrating ingestible capsule, the capsule including:

a housing;

a vibrating agitation mechanism adapted such that, in a vibration mode of operation, said housing exerts vibrations on an environment surrounding the vibrating ingestible capsule;

a power supply disposed within said housing and adapted to power said vibrating agitation mechanism; and

a control mechanism adapted to activate said vibrating agitation mechanism to operate in said vibration mode of operation;

(b) ingesting the ingestible medicament;

(c) ingesting the vibrating ingestible capsule; and

(d) controlling at least one of a time of said ingesting of the vibrating ingestible capsule and a timing or activation delay of said vibration mode of operation, such that said vibration mode of operation at least partially transpires within at least one of an estimated absorption time period and an actual absorption time period of the ingestible medicament within the gastrointestinal tract of the subject.

2. The method of claim 1 , wherein said controlling is effected such that said vibration mode of operation at least partially transpires during said actual absorption time.

3. The method of claim 1 , wherein said actual absorption time period occurs when the ingestible medicament is disposed in a small intestine of the subject.

4. The method of claim 1 , wherein said controlling of is effected such that said vibration mode of operation at least partially transpires during said estimated absorption time.

5. The method of claim 4 , wherein said estimated absorption time is within a range of 0.5 to 5 hours from said ingesting of said ingestible medicament.

6. The method of claim 1 , wherein said ingesting of said vibrating ingestible capsule occurs after said ingesting of said ingestible medicament, and transpires within 4 hours of said ingesting of the ingestible medicament.

7. The method of claim 1 , wherein said ingesting of said vibrating ingestible capsule is simultaneous with said ingesting of the ingestible medicament.

8. The method of claim 1 , further comprising timing said vibration mode of operation to at least partially transpire within 5 hours, within 4 hours, within 3.5 hours, within 3 hours, within 2.5 hours, within 2 hours, within 1.5 hours, within 1 hour, or within 0.5 hours of said ingesting of the ingestible medicament.

9. The method of claim 1 , wherein the ingestible medicament for treatment of an ailment of the GI tract includes at least one of:

at least one osmotic agent;

at least one of magnesium citrate, magnesium hydroxide, polyethylene glycol, or sodium phosphate;

at least one contraction stimulating agent;

at least one of bisacodyl, sennosides, and senna;

at least one stool softening agent;

docusate sodium;

linaclotide;

lactulose;

lubiprostone;

plecanatide;

prucalopride;

at least one fluid absorption agent;

loperamide; and

bismuth subsalicylate.

10. The method of claim 9 , wherein the medicament for treatment of an ailment of the GI tract is adapted to mitigate or retard a development of the ailment of the GI tract.

11. The method of claim 9 , wherein the medicament for treatment of an ailment of the GI tract is adapted to manage a condition of the ailment of the GI tract.

12. The method of claim 1 , wherein said vibration mode of operation at least partially transpiring within at least one of an estimated absorption time period and an actual absorption time period of the ingestible medicament within the gastrointestinal tract of the subject effects an increased absorption of the ingestible medicament for treatment of an ailment of the GI tract, thereby providing at least one of the following impacts:

improving a therapeutic efficacy of the medicament; and

enabling the use of a lower dosage of said medicament than a dosage used without use of said vibrating ingestible capsule, without impairing or diminishing therapeutic efficacy.

13. The method of claim 1 , wherein said vibration mode of operation is effected within the gastrointestinal tract so as to achieve at least one of the following results:

stimulate the enteric nervous system of the subject;

induce at least one peristaltic wave in a wall of the gastrointestinal tract; and

effect increasing peristalsis in a wall of the gastrointestinal tract.

14. The method of claim 1 , wherein, in said vibration mode of operation, a cumulative duration of said vibrating mode of operation is within a range of 1 hour to 12 hours.

15. The method of claim 13 , wherein, in said vibration mode of operation, a cumulative duration of said vibrating mode of operation is within a range of 1 hour to 12 hours.

16. The method of claim 13 , wherein, in said vibration mode of operation:

said vibrating agitation mechanism exerts forces on said housing such that a net force exerted by said housing on said environment is within a range of 50 grams force to 600 grams force; and

said vibrating agitation mechanism exerts said forces on said housing such that a vibrational frequency of said housing is within a range of 10 Hz to 650 Hz.