Neurostimulator with titration assist

1. A method of titrating a neurostimulation signal delivered to a patient from an implantable pulse generator, the method comprising:

delivering a neurostimulation signal in conformance with a first set of parameters, the first set of parameters having a first value for at least one of output current, frequency, pulse width, or duty cycle;

modifying the neurostimulation signal to conform with a second set of parameters, the second set of parameters having a second value for at least one of output current, frequency, pulse width, or duty cycle, the second value being greater in magnitude than the first value;

receiving a hold indicator, the hold indicator being associated with a pre-defined titration hold point defined as the neurostimulation signal conforming with the second set of parameters, the pre-defined titration hold point being defined prior to the neurostimulation signal conforming with the second set of parameters;

initiating an intermediate hold of the titrating of the neurostimulation signal in response to the hold indicator, the intermediate hold being a continuation of the neurostimulation signal conforming with the second set of parameters; and

receiving an indication of a titration resumption that discontinues the intermediate hold,

wherein upon completion of a time interval associated with a subsequent titration step during the intermediate hold, the neurostimulation signal conforming with the second set of parameters is continued, and

wherein upon the completion of the time interval associated with the subsequent titration step after receiving the indication of the titration resumption that discontinues the intermediate hold, the titrating of the neurostimulation signal is resumed in accordance with the subsequent titration step.

2. The method of claim 1 , wherein the receiving of the indication of a titration resumption is preceded by a time interval sufficient to allow the patient to obtain assistance from a health care provider and/or activate a sensor communicating with the implantable pulse generator.

3. The method of claim 1 , further comprising:

subsequent to the receipt of the indication of the titration resumption, delivering the neurostimulation signal in conformance with the second set of parameters; and

modifying the neurostimulation signal to conform with a third set of parameters, the third set of parameters having a third value for at least one of output current, frequency, pulse width, or duty cycle, the third value being greater in magnitude than the second value.

4. The method of claim 3 , wherein the hold indicator is a first hold indicator, the pre-defined titration hold point is a first pre-defined titration hold point, the intermediate hold is a first intermediate hold, and the indication of a titration resumption is a first indication of a titration resumption; and

wherein the method further comprises:

receiving a second hold indicator, the second hold indicator being associated with at least one of a second pre-defined titration hold point or an indication of a side effect experienced by the patient in response to the neurostimulation signal conforming with the third set of parameters;

initiating a second intermediate hold of the titrating of the neurostimulation signal in response to the second hold indicator, the second intermediate hold corresponding to the second pre-defined titration hold point being a continuation of the neurostimulation signal conforming with the third set of parameters, the second intermediate hold corresponding to the indication of the side effect being a return to the neurostimulation signal conforming with the second set of parameters; and

receiving a second indication of a titration resumption that discontinues the second intermediate hold.

5. The method of claim 4 , wherein the receiving of the second indication of a titration resumption is preceded by a time interval sufficient to allow the patient to obtain assistance from a health care provided and/or activate a sensor communication with the implantable pulse generator.

6. The method of claim 1 , further comprising:

subsequent to the receipt of the indication of the titration resumption, delivering the neurostimulation signal in conformance with a third set of parameters, the third set of parameters having a third value for at least one of output current, frequency, pulse width, or duty cycle, the third value being greater in magnitude than the second value; and

modifying the neurostimulation signal to conform with a fourth set of parameters, the fourth set of parameters having a fourth value for at least one of output current, frequency, pulse width, or duty cycle, the fourth value being greater in magnitude than the third value.

7. The method of claim 6 , wherein the hold indicator is a first hold indicator, the pre-defined titration hold point is a first pre-defined titration hold point, the intermediate hold is a first intermediate hold, and the indication of a titration resumption is a first indication of a titration resumption; and

wherein the method further comprises:

receiving a second hold indicator, the second hold indicator being associated with at least one of a second pre-defined titration hold point or an indication of a side effect experienced by the patient in response to the neurostimulation signal conforming with the fourth set of parameters;

initiating a second intermediate hold of the titrating of the neurostimulation signal in response to the second hold indicator, the second intermediate hold corresponding to the second pre-defined titration hold point being a continuation of the neurostimulation signal conforming with the fourth set of parameters, the second intermediate hold corresponding to the indication of the side effect being a return to the neurostimulation signal conforming with at least one of the first, second, or third sets of parameters; and

receiving a second indication of a titration resumption that discontinues the second intermediate hold.

8. The method of claim 7 , wherein the receiving of the second indication of a titration resumption is preceded by a time interval sufficient to allow the patient to obtain assistance from a health care provider and/or activate a sensor communication with the implantable pulse generator.

9. The method of claim 1 , wherein the pre-defined titration hold point corresponds to a titration aggressiveness profile, the titration aggressiveness profile having a more aggressive level and a less aggressive level, the more aggressive level defined by at least one of the following as compared to the less aggressive level:

a shorter time interval associated with a transition from the first set of parameters to the second set of parameters,

a greater target intensity, or

a greater increment value between the first and second values.

10. The method of claim 1 , wherein the indication of the titration resumption is received from an external device indicating instructions to discontinue the intermediate hold.

11. A neurostimulation system capable of providing a neurostimulation signal to a patient, the neurostimulation system comprising:

an implantable pulse generator that generates the neurostimulation signal according to a titration protocol executed by a processor;

an electrode configured to deliver the neurostimulation signal to the patient; and

a lead coupling the electrode to the implantable pulse generator,

wherein the processor is configured to implement the titration protocol by issuing control signals that allow the implantable pulse generator to:

deliver a neurostimulation signal in conformance with a first set of parameters, the first set of parameters having a first value for at least one of output current, frequency, pulse width, or duty cycle;

modify the neurostimulation signal to conform with a second set of parameters, the second set of parameters having a second value for at least one of output current, frequency, pulse width, or duty cycle, the second value being greater in magnitude than the first value;

receive a hold indicator, the hold indicator being associated with a pre-defined titration hold point defined as the neurostimulation signal conforming with the second set of parameters, the pre-defined titration hold point being defined prior to the neurostimulation signal conforming with the second set of parameters;

initiate an intermediate hold of the titrating of the neurostimulation signal in response to the hold indicator, the intermediate hold being a continuation of the neurostimulation signal conforming with the second set of parameters; and

receive an indication of a titration resumption that discontinues the intermediate hold,

wherein upon completion of a time interval associated with a subsequent titration step during the intermediate hold, the neurostimulation signal conforming with the second set of parameters is continued, and

wherein upon completion of the time interval associated with the subsequent titration step after receiving the indication of the titration resumption that discontinues the intermediate hold, the titration protocol is resumed in accordance with the subsequent titration step.

12. The system of claim 11 , wherein the receipt of the indication of a titration resumption is preceded by a time interval sufficient to allow the patient to obtain assistance from a health care provider and/or activate a sensor communicating with the implantable pulse generator.

13. The system of claim 11 , wherein the processor is further configured to issue additional control signals that allow the implantable pulse generator to:

deliver the neurostimulation signal in conformance with the second set of parameters subsequent to the receipt of the indication of the titration resumption; and

modify the neurostimulation signal to conform with a third set of parameters, the third set of parameters having a third value for at least one of output current, frequency, pulse width, or duty cycle, the third value being greater in magnitude than the second value.

14. The system of claim 13 , wherein the hold indicator is a first hold indicator, the pre-defined titration hold point is a first pre-defined titration hold point, the intermediate hold is a first intermediate hold, and the indication of a titration resumption is a first indication of a titration resumption; and

wherein the processor is still further configured to issue still additional control signals that allow the implantable pulse generator to:

receive a second hold indicator, the second hold indicator being associated with at least one of a second pre-defined titration hold point or an indication of a side effect experienced by the patient in response to the neurostimulation signal conforming with the third set of parameters;

initiate a second intermediate hold of the titrating of the neurostimulation signal in response to the second hold indicator, the second intermediate hold corresponding to the second pre-defined titration hold point being a continuation of the neurostimulation signal conforming with the third set of parameters, the second intermediate hold corresponding to the indication of the side effect being a return to the neurostimulation signal conforming with the second set of parameters; and

receive a second indication of a titration resumption that discontinues the second intermediate hold.

15. The system of claim 14 , wherein the receipt of the second indication of a titration resumption is preceded by a time interval sufficient to allow the patient to obtain assistance from a health care provider and/or activate a sensor communicating with the implantable pulse generator.

16. The system of claim 11 , wherein the processor is further configured to issue additional control signals that allow the implantable pulse generator to:

deliver the neurostimulation signal in conformance with a third set of parameters subsequent to the receipt of the indication of the titration resumption, the third set of parameters having a third value for at least one of output current, frequency, pulse width, or duty cycle, the third value being greater in magnitude than the second value; and

modify the neurostimulation signal to conform with a fourth set of parameters, the fourth set of parameters having a fourth value for at least one of output current, frequency, pulse width, or duty cycle, the fourth value being greater in magnitude than the third value.

17. The system of claim 16 , wherein the hold indicator is a first hold indicator, the pre-defined titration hold point is a first pre-defined titration hold point, the intermediate hold is a first intermediate hold, and the indication of a titration resumption is a first indication of a titration resumption; and

wherein the processor is still further configured to issue still additional control signals that allow the implantable pulse generator to:

receive a second hold indicator, the second hold indicator being associated with at least one of a second pre-defined titration hold point or an indication of a side effect experienced by the patient in response to the neurostimulation signal conforming with the fourth set of parameters;

initiate a second intermediate hold of the titrating of the neurostimulation signal in response to the second hold indicator, the second intermediate hold corresponding to the second pre-defined titration hold point being a continuation of the neurostimulation signal conforming with a fourth set of parameters, the second intermediate hold corresponding to the indication of the side effect being a return to the neurostimulation signal conforming with at least one of the first, second, or third sets of parameters; and

receive a second indication of a titration resumption that discontinues the second intermediate hold.

18. The system of claim 17 , wherein the receipt of the second indication of a titration resumption is preceded by a time interval sufficient to allow the patient to obtain assistance from a health care provider and/or activate a sensor communicating with the implantable pulse generator.

19. The system of claim 11 , wherein the pre-defined titration hold point corresponds to a titration aggressiveness profile, the titration aggressiveness profile having a more aggressive level and a less aggressive level, the more aggressive level defined by at least one of the following as compared to the less aggressive level:

a shorter time interval associated with a transition from the first set of parameters to the second set of parameters,

a greater target intensity, or

a greater increment value between the first and second values.

20. The system of claim 11 , wherein the indication of the titration resumption is received from a health care provider device indicating instructions from a health care provider to discontinue the intermediate hold.