Pyrazole compound

1. A process for preparing a compound of Formula (A-4):

or a pharmaceutically acceptable salt thereof, wherein

R 1 is selected from the group consisting of a hydrogen atom, a C 1-6 alkyl group, and a C 3-8 cycloalkyl group,

R 3 and R 4 are independently selected from the group consisting of a hydrogen atom and a C 1-6 alkyl group,

R 5 is an optionally-substituted C 4-7 alkyl group or —(CR 8 R 9 ) r -E,

R 6 , R 7 , R 8 , and R 9 are independently selected from the group consisting of a hydrogen atom, a fluorine atom, and an optionally-substituted C 1-6 alkyl group,

A is an optionally-substituted C 6-10 aryl group or an optionally-substituted 5- to 10-membered heteroaryl group,

r is 1, 2, 3, or 4,

E is an optionally-substituted C 3-8 cycloalkyl group, an optionally-substituted C 4-8 cycloalkenyl group, an optionally-substituted 5- to 10-membered saturated heterocyclic group which comprises 1 to 3 heteroatoms independently selected from the group consisting of an oxygen atom and a sulfur atom as a constituent atom of the ring, an optionally-substituted C 6-10 aryl group, or an optionally-substituted 5- to 10-membered heteroaryl group,

L a is an oxygen atom or a sulfur atom, and

n is 1, 2, or 3,

which comprises the following Steps (i) and (ii):

Step (i): reacting a compound of Formula (A-1):

or a salt thereof, wherein R 1 , R 3 , R 4 , R 5 , and L a are the same as defined above and PG is a protecting group on amino groups,

with a compound of Formula (A-2):

wherein R 6 , R 7 , and n are the same as defined above and LG is a leaving group,

to obtain a compound of Formula (A-3):

or a salt thereof, wherein R 1 , R 3 , R 4 , R 5 , R 6 , R 7 , L a , n, and PG are the same as defined above, and

Step (ii): deprotecting the protecting group of the compound of Formula (A-3) to obtain the compound of Formula (A-4).

2. A process for preparing a compound of Formula (A-12):

or a pharmaceutically acceptable salt thereof, which comprises the following Steps (i) to (v):

Step (i): reacting a compound of Formula (B-7):

with a compound of Formula (B-4):

or a salt thereof,

to obtain a compound of Formula (B-8):

Step (ii): reacting the compound of Formula (B-8) with a compound of Formula (A-2):

to obtain a compound of Formula (A-13):

Step (iii): converting the compound of Formula (A-13) to a compound of Formula (B-9):

Step (iv): converting the compound of Formula (B-9) to a compound of Formula (A-10):

and

Step (v): reacting the compound of Formula (A-10) with a compound of Formula (A-11):

or a salt thereof,

to obtain the compound of Formula (A-12),

wherein

R 1 and R 2 are independently selected from the group consisting of a hydrogen atom and a C 1-6 alkyl group,

R 3 and R 4 are independently selected from the group consisting of a hydrogen atom and a methyl group,

R 5 is an optionally-substituted C 4-7 alkyl group or —(CR 8 R 9 ) r -E,

R 6 and R 7 are hydrogen atoms,

R 8 and R 9 are independently selected from the group consisting of a hydrogen atom, a fluorine atom, and an optionally-substituted C 1-6 alkyl group,

A is an optionally-substituted C 6-10 aryl group or an optionally-substituted 5- to 10-membered heteroaryl group,

r is 1 or 2,

E is an optionally-substituted C 3-8 cycloalkyl group, an optionally-substituted C 4-8 cycloalkenyl group, an optionally-substituted 5- to 10-membered saturated heterocyclic group which comprises 1 to 3 heteroatoms independently selected from the group consisting of an oxygen atom and a sulfur atom as a constituent atom of the ring, an optionally-substituted C 6-10 aryl group, or an optionally-substituted 5- to 10-membered heteroaryl group, and

n is 1,

R a is hydrogen atom or a C 1-6 alkyl group,

M 1 is hydrogen atom, an alkali metal, or an alkaline earth metal, and

LG is a leaving group.