Use of cannabinoids in the treatment of epilepsy
The present disclosure relates to the use of cannabidiol (CBD) for the treatment of atonic seizures. In particular the CBD appears particularly effective in reducing atonic seizures in patients suffering with etiologies that include: Lennox-Gastaut Syndrome; Tuberous Sclerosis Complex; Dravet Syndrome; Doose Syndrome; Aicardi syndrome; CDKL5 and Dup15q in comparison to other seizure types. The disclosure further relates to the use of CBD in combination with one or more anti-epileptic drugs (AEDs).
1. A method of treating drop seizures in a patient with Lennox-Gastaut syndrome or Dravet syndrome, comprising administering to the patient cannabidiol (CBD), wherein the CBD has a purity of at least 95% (w/w), and the CBD is administered at a dose of 5 mg/kg/day, and then the dose is increased by 2 to 5 mg/kg increments, up to 25 mg/kg/day.
2. The method of claim 1 , wherein the CBD comprises Δ9-tetrahydrocannabinol (THC).
3. The method of claim 2 , wherein the CBD comprises not more than 0.15% (w/w) Δ9-tetrahydrocannabinol (THC).
4. The method of claim 1 , wherein the dose of the CBD is increased to a dose ranging from 10 mg/kg/day to 25 mg/kg/day.
5. The method of claim 1 , wherein the dose of the CBD is increased to a dose ranging from 10 mg/kg/day to 20 mg/kg/day.
6. The method of claim 1 , wherein the CBD has a purity of at least 98% (w/w).
7. The method of claim 1 , wherein the dose of the CBD is increased to about 25 mg/kg/day.
8. The method of claim 1 , wherein the dose of the CBD is increased to about 10 mg/kg/day.
9. The method of claim 1 , wherein the dose of the CBD is increased to about 12 mg/kg/day.
10. The method of claim 1 , wherein the dose of the CBD is increased to about 14 mg/kg/day.
11. The method of claim 1 , wherein the dose of the CBD is increased to about 15 mg/kg/day.
12. The method of claim 1 , wherein the dose of the CBD is increased to about 18 mg/kg/day.
13. The method of claim 1 , wherein the dose of the CBD is increased to about 20 mg/kg/day.
14. The method of claim 1 , wherein the patient has Lennox-Gastaut Syndrome.
15. The method of claim 1 , wherein the patient has Dravet syndrome.
16. The method according to claim 1 , wherein the CBD is administered in combination with one or more concomitant anti-epileptic drugs (AED) to the patient at a recommended therapeutic dose.
17. The method according to claim 16 , wherein the one or more AED is selected from the group consisting of: clobazam; clonazepam, levetiracetam; topiramate; stiripentol; phenobarbital; lacosamide; valproic acid; zonisamide; perampanel; and fosphenytoin.
18. The method according to claim 16 , wherein the number of different AED that are administered in combination with the CBD to the patient is reduced.
19. The method according to claim 16 , wherein the recommended therapeutic dose of the one or more AED that are administered in combination with the CBD is reduced from the recommended therapeutic dose without CBD.
20. A method of treating drop seizures in a patient with Lennox-Gastaut syndrome or Dravet syndrome, comprising administering to the patient cannabidiol (CBD), wherein the CBD has a purity of at least 95% (w/w), and wherein the CBD is administered at a dose ranging from 5 mg/kg/day to 20 mg/kg/day.
21. The method of claim 20 , wherein the CBD has a purity of at least 98% (w/w).
22. The method of claim 20 , wherein the dose of the CBD is from 10 mg/kg/day to 20 mg/kg/day.
23. The method of claim 20 , wherein the dose of the CBD is about 10 mg/kg/day.
24. The method of claim 20 , wherein the dose of the CBD is about 12 mg/kg/day.
25. The method of claim 20 , wherein the dose of the CBD is about 14 mg/kg/day.
26. The method of claim 20 , wherein the dose of the CBD is about 15 mg/kg/day.
27. The method of claim 20 , wherein the dose of the CBD is about 18 mg/kg/day.
28. The method of claim 20 , wherein the dose of the CBD is about 20 mg/kg/day.
29. The method of claim 20 , wherein the CBD comprises not more than 0.15% (w/w) Δ9-tetrahydrocannabinol (THC).
30. The method of claim 20 , wherein the dose of the CBD is administered at a starting dose of 5 mg/kg/day, and then the dose is increased by 2 to 5 mg/kg increments.
31. The method of claim 20 , wherein the patient has Lennox-Gastaut Syndrome.
32. The method of claim 20 , wherein the patient has Dravet syndrome.