Mesenchymal stem cells and uses therefor
Compositions and methods of promoting wound healing in a human by administering to the human mesenchymal stem cells in an effective amount.
1. A method of reducing inflammation in the gut, skin, or liver in a patient in need thereof comprising administering cultured mesenchymal stem cells to the patient in an amount effective to reduce the inflammation, wherein the mesenchymal stem cells are not genetically engineered with one or more polynucleotides encoding a therapeutic agent.
2. The method of claim 1 , wherein the mesenchymal stem cells are allogeneic.
3. The method of claim 1 , wherein the mesenchymal stem cells are autologous.
4. The method of claim 1 , wherein the mesenchymal stem cells are administered as a cell suspension in a pharmaceutically acceptable liquid medium for inj ecti on.
5. The method of claim 1 , wherein the mesenchymal stem cells are administered intravenously.
6. The method of claim 1 , wherein the mesenchymal stem cells are administered intraarterially.
7. The method of claim 1 , wherein the mesenchymal stem cells are administered in amount of about 1×10 5 cells/kg to about 5×10 7 cells per kg.
8. The method of claim 1 , wherein the mesenchymal stem cells are administered in amount of about 1×10 6 cells/kg to about 5×10 6 cells per kg.
9. The method of claim 1 , wherein the mesenchymal stem cells were isolated from marrow.
10. The method of claim 9 , wherein the marrow is iliac crest marrow.
11. The method of claim 1 , wherein the mesenchymal stem cells were isolated from blood, skin, cord blood, muscle, fat, bone, or perichondrium.
12. The method of claim 2 , wherein the mesenchymal stem cells are administered as a cell suspension in a pharmaceutically acceptable liquid medium for injection.
13. The method of claim 2 , wherein the mesenchymal stem cells are administered intravenously.
14. The method of claim 2 , wherein the mesenchymal stem cells are administered intraarterially.
15. The method of claim 2 , wherein the mesenchymal stem cells are administered in amount of about 1×10 5 cells/kg to about 5×10 7 cells per kg.
16. The method of claim 2 , wherein the mesenchymal stem cells are administered in amount of about 1×10 6 cells/kg to about 5×10 6 cells per kg.
17. The method of claim 2 , wherein the mesenchymal stem cells were isolated from marrow.
18. The method of claim 17 , wherein the marrow is iliac crest marrow.
19. The method of claim 2 , wherein the mesenchymal stem cells were isolated from blood, skin, cord blood, muscle, fat, bone, or perichondrium.
20. The method of claim 1 , wherein inflammation in the gut is reduced.
21. The method of claim 1 , wherein inflammation in the skin is reduced.
22. The method of claim 1 , wherein inflammation in the liver is reduced.