Topical compositions and methods of use thereof
The present invention is directed to topical compositions containing botulinum toxin, benzoyl peroxide, salicylic acid or a mixture of benzoyl peroxide and salicylic acid. The present invention is further directed to methods of treating acne or reducing rhytides with these topical compositions.
1. A topical composition comprising botulinum toxin, polysorbate 80, poloxamer 407, poloxamer 188, polyoxyl castor oil, hydroxypropyl-gamma-cyclodextrin, hydroxypropylmethyl cellulose, mannitol, magnesium chloride, and sodium chloride.
2. The composition of claim 1 , comprising:
from about 50 to about 200 units of botulinum toxin;
from about 0.5% to about 3.5% w/v polysorbate 80;
from about 0.2% to about 0.5% w/v poloxamer 407;
from about 0.1% to about 1.5% w/v poloxamer 188;
from about 0.015% to about 0.5% w/v polyoxyl castor oil;
from about 0.5% to about 5.0% w/v hydroxypropyl-gamma-cyclodextrin;
from about 0.5% to about 1.25% w/v hydroxypropylmethyl cellulose;
from about 0.5% to about 1.0% w/v polyethylene glycol 400;
from about 1.0% to about 4.0% w/v mannitol;
from about 0.075% to about 0.125% w/v magnesium chloride; and
from about 0.1% to about 0.5% w/v sodium chloride,
wherein w/v denotes weight by total volume of the composition.
3. The composition of claim 2 , further comprising from about 0.1 to about 0.5 millimolar menthol.
4. The composition of claim 3 , further comprising from about 0.005% to about 0.02% w/v benzalkonium chloride and from about 0.05% to about 0.15% w/v disodium ethylenediaminetetraacetic acid.
5. A topical composition comprising:
about 100 units of botulinum toxin;
about 3.0% w/v polysorbate 80;
about 0.2% w/v poloxamer 407;
about 1.5% w/v poloxamer 188;
about 0.5% w/v polyoxyl castor oil;
about 1.5% w/v hydroxypropyl-gamma-cyclodextrin;
about 0.75% w/v hydroxypropylmethyl cellulose;
about 0.5% w/v polyethylene glycol 400;
about 1.0% w/v mannitol;
about 0.1% w/v magnesium chloride; and
about 0.4% w/v sodium chloride,
wherein w/v denotes weight by total volume of the composition.
6. The composition of claim 5 , further comprising from about 0.25 to about 0.35 millimolar menthol.
7. The composition of claim 6 , further comprising about 0.02% w/v benzalkonium chloride and about 0.1% w/v disodium ethylenediaminetetraacetic acid.
8. A method of treating rhytides comprising topically applying the composition of claim 1 to a person in need thereof.