Mesenchymal stem cells and uses therefor
Compositions and methods of promoting wound healing in a human by administering to the human mesenchymal stem cells in an effective amount.
1. A method of treating an allergic disease or disorder in a human, said method comprising administering mesenchymal stem cells to the human in an amount effective to treat the allergic disease or disorder.
2. The method of claim 1 , wherein the mesenchymal stem cells are genetically unmanipulated.
3. The method of claim 1 , wherein the mesenchymal stem cells are allogeneic.
4. The method of claim 2 , wherein the mesenchymal stem cells are allogeneic.
5. The method of claim 1 , wherein the allergic disease or disorder is asthma, allergic rhinitis, atopic dermatitis, or contact dermatitis.
6. The method of claim 2 , wherein the allergic disease or disorder is asthma, allergic rhinitis, atopic dermatitis, or contact dermatitis.
7. The method of claim 3 , wherein the allergic disease or disorder is asthma, allergic rhinitis, atopic dermatitis, or contact dermatitis.
8. The method of claim 4 , wherein the allergic disease or disorder is asthma, allergic rhinitis, atopic dermatitis, or contact dermatitis.
9. The method of claim 1 , wherein the mesenchymal stem cells are administered systemically.
10. The method of claim 1 , wherein the mesenchymal stem cells are administered intravenously or intraarterially.
11. The method of claim 5 , wherein the mesenchymal stem cells are administered intravenously or intraarterially.
12. The method of claim 1 , wherein the mesenchymal stem cells are cultured.
13. The method of claim 5 , wherein the mesenchymal stem cells are cultured.
14. The method of claim 1 , wherein the mesenchymal stem cells are administered in an amount from about 1×10 5 cells/kg to about 1×10 7 cells/kg.
15. The method of claim 1 , wherein the mesenchymal stem cells are administered in an amount from about 1×10 6 cells/kg to about 5×10 6 cells/kg.
16. The method of claim 1 , wherein the mesenchymal stem cells were isolated from marrow.
17. The method of claim 16 , wherein the marrow is iliac crest marrow.
18. The method of claim 1 , wherein the mesenchymal stem cells were isolated from blood, skin, cord blood, muscle, fat, bone, or perichondrium.
19. A method of treating asthma in an human, said method comprising intravenously or intraarterially administering genetically unmanipulated allogeneic cultured mesenchymal stem cells to the human in an amount effective to treat the asthma.