Systems and methods for personalized clinical applications of accelerated theta-burst stimulation
Systems and methods for treatment of neurological conditions using aTBS in accordance with embodiments of the invention are illustrated. One embodiment includes a method for treating neurological conditions, including generating a personalized accelerated theta burst stimulation (aTBS) target representing a location in a patient's brain related to a neurological condition, placing a TMS device relative to the patient's brain such that the focus of the magnetic field is over the aTBS target, applying TMS to the aTBS target according to an aTBS protocol to the brain using the TMS device to alleviate the neurological condition.
1. A method for treating neurological conditions, comprising:
generating a personalized accelerated intermittent theta burst stimulation (aiTBS) target representing a location in a patient's brain related to a neurological condition;
placing a transcranial magnetic stimulation (TMS) device relative to the patient's brain such that a focus of the magnetic field is over the aiTBS target; and
applying magnetic stimulation to the aiTBS target using the TMS device on a plurality of consecutive days;
where application of the magnetic stimulation on each day in the plurality of consecutive days takes place during a plurality of sessions;
where each session is separated by an intersession interval lasting between 25 and 120 minutes during which no magnetic stimulation is applied; and
during each session in the plurality of sessions, the TMS device is configured to provide the magnetic stimulation by generating a plurality of pulse trains that each comprise a set of pulses, where each set of pulses is separated by an intertrain interval.
2. The method of claim 1 , wherein each pulse in each set of pulses is between 20 Hz and 70 Hz, and pulses in each set of pulses are applied at between 3 Hz to 7 Hz.
3. The method of claim 2 , wherein the pulse trains are applied between every 4 to 10 seconds for each session in the plurality of sessions; and
wherein each session in the plurality of sessions lasts between 3 and 15 minutes.
4. The method of claim 3 , wherein the plurality of sessions for a given day comprises between 3 and 15 sessions.
5. The method of claim 1 , wherein each session in the plurality of sessions for a given day comprises applying a set of 2 second pulse trains,
where each train comprises magnetic stimulation pulses in the form of three, 50 Hz pulses applied at 5 Hz, where the intertrain interval is 10 seconds, for at least ten, 10 minute sessions, and where the intersession interval is 50 minutes.
6. The method of claim 1 , wherein generating an aiTBS target comprises obtaining a first functional magnetic resonance imaging (fMRI) image data describing a resting state of the patient's brain prior to the treatment.
7. The method of claim 6 , further comprising:
obtaining a second fMRI image data describing the resting state of the patient's brain after the treatment; and
locating differences between the first fMRI image data and the second fMRI image data to confirm efficacy of the aiTBS.
8. The method of claim 1 , wherein the neurological condition is clinical depression.
9. The method of claim 1 , wherein the neurological condition is suicidal ideation.
10. A method for treating neurological conditions, comprising:
generating a personalized accelerated continuous theta burst stimulation (acTBS) target representing a location in a patient's brain related to a neurological condition;
placing a transcranial magnetic stimulation (TMS) device relative to the patient's brain such that a focus of the magnetic field is over the acTBS target; and
applying magnetic stimulation to the acTBS target using the TMS device on a plurality of consecutive days;
where application of the magnetic stimulation on each day in the plurality of consecutive days takes place during a plurality of sessions;
where each session is separated by an intersession interval lasting between 10 and 50 minutes during which no magnetic stimulation is applied; and
during each session in the plurality of sessions, the TMS device is configured to provide the magnetic stimulation by generating a plurality of pulse trains that each comprise a set of pulses.
11. The method of claim 10 , wherein each pulse in each set of pulses is between 20 Hz to 70 Hz, and pulses in each set of pulses are applied at between 3 Hz to 7 Hz; and
wherein each session in the plurality of sessions lasts between 40 and 44 seconds.
12. The method of claim 11 , wherein the plurality of sessions for a given day comprise between 10 and 40 sessions.
13. The method of claim 10 , wherein each session in the plurality of sessions for a given day comprises a set of 3-pulse trains, where each pulse is 50 Hz applied at 5 Hz; and wherein each session in the plurality of sessions lasts 40 seconds.
14. The method of claim 10 , wherein each session in the plurality of sessions for a given day comprises a set of 3-pulse trains, where each pulse in each 3-pulse train is 30 Hz; wherein pulses in each 3-pulse train are applied at 6 Hz; and wherein each session in the plurality of sessions for the given day lasts 44 seconds.
15. The method of claim 10 , wherein generating an acTBS target comprises obtaining a first functional magnetic resonance imaging (fMRI) image data describing a resting state of the patient's brain prior to the treatment.
16. The method of claim 15 , further comprising:
obtaining a second fMRI image data describing the resting state of the patient's brain after the treatment; and
locating differences between the first fMRI image data and the second fMRI image data to confirm efficacy of the acTBS.
17. The method of claim 10 , wherein the neurological condition is clinical depression.
18. The method of claim 10 , wherein the neurological condition is suicidal ideation.
19. A system for treating neurological conditions, comprising:
a transcranial magnetic stimulation (TMS) coil configured to apply magnetic stimulation to an an accelerated intermittent Theta-Burst Stimulation (aiTBS) target in a patient's brain on a plurality of consecutive days;
wherein the system is further configured to apply the magnetic stimulation on each day in the plurality of consecutive days which takes place during a plurality of sessions;
wherein the system is further configured to separate each session by an intersession interval lasting between 10 and 50 minutes during which no magnetic stimulation is applied; and
wherein during each session in the plurality of sessions, the TMS device is configured to provide the magnetic stimulation by generating a plurality of pulse trains that each comprise a set of pulses, wherein each set of pulses is separated by an intertrain interval.
20. The system of claim 19 , wherein each pulse in each set of pulses is between 20 Hz and 70 Hz, and pulses in each set of pulses are applied at between 3 Hz to 7 Hz.
21. The system of claim 20 , wherein the pulse trains are applied between every 4 to 10 seconds for each session in the plurality of sessions; and
wherein each session in the plurality of sessions lasts between 3 and 15 minutes.
22. The system of claim 21 , wherein the plurality of sessions for a given day comprises between 3 and 15 sessions.
23. The system of claim 19 , wherein each session in the plurality of sessions for a given day comprises applying a set of 2 second pulse trains,
where each train comprises magnetic stimulation pulses in the form of three, 50 Hz pulses applied at 5 Hz, where the intertrain interval is 10 seconds, for at least ten, 10 minute sessions, and where the intersession interval is 50 minutes.
24. A system for treating neurological conditions, comprising:
a transcranial magnetic stimulation (TMS) coil configured to apply magnetic stimulation to an an accelerated continuous Theta-Burst Stimulation (acTBS) target in a patient's brain on a plurality of consecutive days;
wherein the system is further configured to apply the magnetic stimulation on each day in the plurality of consecutive days which takes place during a plurality of sessions;
wherein the system is further configured to separate each session by an intersession interval lasting between 10 and 50 minutes during which no magnetic stimulation is applied; and
wherein during each session in the plurality of sessions, the TMS device is configured to provide the magnetic stimulation by generating a plurality of pulse trains that each comprise a set of pulses.
25. The system of claim 24 , wherein each pulse in each set of pulses is between 20 Hz to 70 Hz, and pulses in each set of pulses are applied at between 3 Hz to 7 Hz; and
wherein each session in the plurality of sessions lasts between 40 and 44 seconds.
26. The system of claim 25 , wherein the plurality of sessions for a given day comprises between 10 and 40 sessions.
27. The system of claim 24 , wherein each session in the plurality of sessions comprises a set of 3-pulse trains, where each pulse is 50 Hz applied at 5 Hz; and wherein each session in the plurality of sessions lasts 40 seconds.
28. The system of claim 24 , wherein each session in the plurality of sessions for a given day comprises a set of 3-pulse trains, where each pulse in each 3-pulse train is 30 Hz; wherein pulses in each 3-pulse train are applied at 6 Hz; and wherein each session in the plurality of sessions for the given day lasts 44 seconds.