NONSTEROIDAL IMMUNOMODULATING KIT AND COMPOSITION AND USES THEREOF
A composition and therapeutic kit including an aerosol packaging assembly including a container accommodating a pressurized product and an outlet capable of releasing a foamable composition, including a nonsteroidal immunomodulating agent as a foam. The pressurized product includes a foamable composition including: a) a container accommodating a pressurized product; and b) an outlet capable of releasing the pressurized product as a foam; wherein the pressurized product comprises a foamable composition including: i. a nonsteroidal immunomodulating agent; ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, a polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight; iii. a surface-active agent; iv. about 0.1% to about 5% by weight of a therapeutically active foam adjuvant, selected from the group consisting of a fatty alcohol, a fatty acid, a hydroxyl fatty acid; and mixtures thereof; v. about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; vi. water; and vii. liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
1 - 32 . (canceled)
33 . A method of treating an inflammatory disorder of skin, a body cavity, or a mucosal surface, comprising administering topically to a subject having the disorder a foam composition,
wherein the foam composition comprises:
a) a therapeutically effective amount of a nonsteroidal immunomodulating agent;
b) at least one organic carrier selected from a hydrophobic organic carrier, a polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight;
c) a surface-active agent at a concentration of about 0.1% to about 5% by weight;
d) a polymeric additive, at a concentration of about 0.01% to about 5% by weight, selected from a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent;
e) a foam adjuvant at a concentration of about 0.1% to about 5% by weight; and
f) water.