Method of characterizing tissue of a patient
A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.
1. A system for characterizing a tissue volume of a patient, comprising:
a processor configured with instructions to:
receive an acoustic data set derived from acoustic waves detected by a transducer;
generate two or more renderings of the tissue volume from the acoustic data set, wherein the two or more renderings comprise a first rendering representing a distribution of acoustic reflection within the tissue volume and a second rendering representing a distribution of acoustic attenuation or a distribution of acoustic speed within the tissue volume:
generate a merged rendering of the tissue volume from at least the first rendering and the second rendering;
identify a region of interest from the merged rendering;
determine a qualitative prognostic parameter, wherein the qualitative prognostic parameter characterizes a margin of the region of interest identified from the merged rendering according to an integer scale;
determine a quantitative prognostic parameter for the region of interest identified from the second rendering, wherein the at least one quantitative prognostic parameter comprises an attenuation value or a speed value; and
output an analysis of the region of interest derived at least from the quantitative prognostic parameter and the qualitative prognostic parameter, wherein the analysis is indicative of a presence of cancer within the tissue volume.
2. The system of claim 1 , wherein the processor is configured to identify an outline of the region of interest from the merged rendering.
3. The system of claim 1 , wherein the processor is configured to identify an outline of the region of interest in the first rendering or the second rendering and replicate the outline of the region of interest in the merged rendering to identify the outline of the region of interest from the merged rendering.
4. The system of claim 1 , wherein the processor is configured to characterize the region of interest as at least one of: a cancerous tumor, a fibroadenoma, a cyst, a nonspecific benign mass, and an unidentifiable mass.
5. The system of claim 1 , wherein the processor is configured to determine a volume average value of attenuation or a volume average value of speed.
6. The system of claim 1 , wherein the first rendering and the second rendering comprise two-dimensional images.
7. The system of claim 1 , wherein the first rendering and the second rendering comprise three-dimensional images.
8. The system of claim 1 , wherein the merged rendering is a two-dimensional rendering.
9. The system of claim 1 , wherein the merged rendering is a three-dimensional rendering.
10. The system of claim 1 , further comprising the transducer, wherein the transducer comprises a receiver configured to detect the acoustic waves from the tissue volume.
11. The system of claim 10 , wherein the transducer comprises a plurality of receivers configured to detect the acoustic waves from the tissue volume.
12. The system of claim 1 , further comprising the transducer, wherein the transducer comprises a transmitter configured to emit the acoustic waves towards the tissue volume.
13. The system of claim 12 , wherein the transducer comprises a plurality of transmitters configured to emit the acoustic waves towards the tissue volume.
14. The system of claim 1 , further comprising the transducer, wherein the transducer comprises a ring-shaped transducer configured to surround the tissue volume.
15. The system of claim 1 , wherein the processor is configured to navigate a decision tree that compares at least one of the quantitative prognostic parameter and the qualitative prognostic parameter of the region of interest to a threshold.
16. The system of claim 1 , further comprising a display in communication with the processor, wherein the display is configured to display rendered information derived from the analysis.
17. The system of claim 1 , further comprising an imaging tank configured to receive the tissue volume.
18. The system of claim 4 , wherein the analysis of the region of interest comprises characterizing the region of interest as benign if the qualitative prognostic parameter is below a first threshold value on the integer scale and the quantitative prognostic parameter is below a second threshold value.
19. The system of claim 4 , wherein the analysis of the region of interest comprises characterizing the region of interest as cancerous if the qualitative prognostic parameter is above a first threshold value on the integer scale and the quantitative prognostic parameter is above a second threshold value.
20. The system of claim 1 , wherein the quantitative prognostic parameter is derived from multiple patient exams performed at different intervals of time.