IP Library › Granted Patent US 10,487,090
Granted Patent B2
US 10,487,090 · App. 16/217,935 · Granted Nov 26, 2019

Solid forms of a thienopyrimidinedione ACC inhibitor and methods for production thereof

Inventors: Selcuk Calimsiz (Foster City, CA); Michael Geier (Foster City, CA); Geraldine C. Harriman (Charlestown, RI); Jon P. Lawson (Cambridge, MA); Kyle Sabourin (Foster City, CA); Mark E. Scott (Foster City, CA); Vimal Varghese (Foster City, CA); Xiaotian Wang (Foster City, CA); Xiaowei Yang (Foster City, CA)
Assignee: Gilead Apollo, LLC
C07D495/04A61K31/519A61P1/16A61P3/00A61P3/06C07D309/12C12P41/001C12Y301/01003C07B2200/13
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Quick Facts
Patent No.
US 10,487,090
App. No.
16/217,935
Granted
Nov 26, 2019
Kind
B2
Abstract

The present invention provides solid forms of compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, methods of producing the same, and methods of using the same in the treatment of ACC-mediated diseases.

Claims (7)

1. A process for preparing compound G-4-a:

comprising contacting compound G-9-a:

with a compound H-1:

wherein R H is halogen.

2. The process of claim 1 , wherein R H is bromo.

3. The process of claim 1 , wherein preparing a compound G-9-a comprises contacting a compound G-2-a:

with oxazole under conditions sufficient to form compound G-9-a.

Assignments (20)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2019
From: YANG, XIAOWEI
To: PHARMARON BEIJING CO., LTD.; PHARMARON, INC.
Reel/Frame 049568/0460 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2019
From: J.P. LAWSON CONSULTING LLC
To: PHARMACEUTICAL ADVISORS LLC
Reel/Frame 049569/0201 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2019
From: AMEDIO CMC CONSULTING, LLC
To: NIMBUS DISCOVERY, INC.
Reel/Frame 049569/0568 →
CHANGE OF NAME Recorded Jun 24, 2019
From: NIMBUS APOLLO, INC.
To: GILEAD APOLLO, INC.
Reel/Frame 049569/0680 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2019
From: HU, SIJUN
To: PHARMARON BEIJING CO., LTD.; PHARMARON, INC.
Reel/Frame 049567/0784 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2019
From: PHARMARON BEIJING CO., LTD.; PHARMARON, INC.
To: PHARMARON, INC.
Reel/Frame 049567/0970 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2019
From: GILEAD SCIENCES, INC.
To: GILEAD APOLLO, LLC
Reel/Frame 049568/0535 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2019
From: HARRIMAN, GERALDINE C.
To: NIMBUS DISCOVERY, INC.
Reel/Frame 049566/0212 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2019
From: LAWSON, JON P.
To: J.P. LAWSON CONSULTING LLC
Reel/Frame 049567/0213 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2019
From: PHARMACEUTICAL ADVISORS LLC
To: NIMBUS APOLLO, INC.
Reel/Frame 049567/0250 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2019
From: AMEDIO, JOHN C., JR.
To: AMEDIO CMC CONSULTING, LLC
Reel/Frame 049567/0413 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2019
From: PHARMARON, INC.
To: NIMBUS APOLLO, INC.
Reel/Frame 049567/0552 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 21, 2019
From: HARRIMAN, GERALDINE C.
To: NIMBUS DISCOVERY, INC.
Reel/Frame 049550/0692 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 21, 2019
From: NIMBUS DISCOVERY, INC.
To: NIMBUS APOLLO, INC.
Reel/Frame 049550/0146 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 21, 2019
From: SOLID FORM SOLUTIONS LIMITED
To: NIMBUS APOLLO, INC.
Reel/Frame 049550/0256 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 20, 2019
From: VARIA, KUNAL A.
To: SOLID FORM SOLUTIONS LIMITED
Reel/Frame 049544/0015 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 20, 2019
From: SOLID FORM SOLUTIONS LIMITED
To: NIMBUS DISCOVERY, INC.
Reel/Frame 049544/0079 →
CHANGE OF NAME Recorded Jun 20, 2019
From: GILEAD APOLLO, INC.
To: GILEAD APOLLO, LLC
Reel/Frame 049551/0329 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 20, 2019
From: ALEXANDER, KATY
To: SOLID FORM SOLUTIONS LIMITED
Reel/Frame 049551/0404 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 20, 2019
From: CALIMSIZ, SELCUK; GEIER, MICHAEL; SABOURIN, KYLE; SCOTT, MARK E.; VARGHESE, VIMAL; WANG, XIAOTIAN; MORRISON, HENRY
To: GILEAD SCIENCES, INC.
Reel/Frame 048388/0197 →
Continuity (4)
Division 15446873 · Mar 1, 2017
Provisional Application 62302755 · Mar 2, 2016
Provisional Application 62303237 · Mar 3, 2016
Related Publication 20190225623A1 · Jul 25, 2019
Cited By (1)
US 12,264,145