Mild surfactant preparation and method therefor
A method of selecting a surfactant system suitable for infants and young children is disclosed.
1. A method of evaluating a potential impact of a surfactant system on infant skin, comprising:
a) topically applying said surfactant system in a non-invasive method to adult intact skin
b) topically applying a marker to said surfactant system treated adult skin;
c) applying confocal analysis to measure penetration of said marker into said surfactant system treated adult skin;
d) applying a computational model of adult skin penetration to visualize penetration of the marker by optimizing penetration parameters so that the model of adult skin penetration profiles match the experimental data;
e) transferring the optimized penetration parameters to a computational model of infant skin; and
f) determining the penetration of the marker in the computational model of infant skin.
2. The method of claim 1 , wherein the marker is caffeine.
3. The method of claim 1 , wherein the EPISIM platform is employed as the computational model of adult skin penetration.
4. The method of claim 1 , wherein the computational model of adult skin penetration is an agent-based model.
5. The method of claim 1 , wherein the penetration parameters to be optimized are selected from the group consisting of local surface concentration and permeability coefficient.
6. The method of claim 1 , wherein the marker has a traceable signal.
7. The method of claim 6 , wherein the traceable signal is traceable using confocal analysis.
8. The method of claim 7 , wherein the confocal analysis is selected from confocal Raman micro-spectrometry and confocal fluorescence microscopy.