Coatings containing multiple drugs
A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.
1. A pharmaceutical product comprising:
a. a core,
b. a coating deposited on said core, said coating comprising at least one pharmaceutical layer comprising a pharmaceutical agent having a morphology that is crystalline or semi-crystalline, and
c. at least one polymer layer in dry powder form deposited on said at least one pharmaceutical layer, said at least one polymer layer comprising a sintered layer in which the morphology of said pharmaceutical agent in said coating has not been modified, said at least one polymer layer having a thickness of from about 1 μm to about 100 μm such that at least a portion of said at least pharmaceutical layer is at the surface of said coating.
2. The pharmaceutical product of claim 1 , wherein said at least one polymer layer comprises a bioabsorbable polymer.
3. The pharmaceutical product of claim 1 , wherein said polymer of said at least one polymer layer is selected from PLA, PLGA, PGA, and Poly(dioxanone).
4. The pharmaceutical product of claim 1 , wherein said coating comprises five or more layers, as follows:
a first polymer layer;
a first pharmaceutical layer comprising said at least one pharmaceutical layer;
a second polymer layer;
a second pharmaceutical layer comprising said at least one pharmaceutical layer comprising a pharmaceutical agent having a morphology that is crystalline or semi-crystalline; and
a third polymer layer comprising said at least one polymer layer in dry powder form.
5. The pharmaceutical product of claim 1 , wherein said coating comprises four or more layers, as follows:
a first polymer layer;
a first pharmaceutical layer comprising said at least one pharmaceutical layer;
a second polymer layer; and
a second pharmaceutical layer comprising said at least one pharmaceutical layer comprising a pharmaceutical agent having a morphology as crystalline or semi-crystalline.
6. The pharmaceutical product of claim 1 , comprising four or more layers, as follows:
the first pharmaceutical layer comprising a first pharmaceutical layer;
a first polymer layer;
a second pharmaceutical layer comprising said at least one pharmaceutical layer comprising a pharmaceutical agent having a morphology that is crystalline or semi-crystalline; and
a second polymer layer comprising said at least one polymer layer in dry powder form.
7. The pharmaceutical product of claim 1 , wherein said pharmaceutical layer and said at least one polymer layer comprise alternate layers of pharmaceutical agent, or pharmaceutical agent and polymer, and layers of polymer without pharmaceutical agents.
8. A pharmaceutical product comprising:
a coating composition comprising a plurality of polymer layers,
a pharmaceutical layer comprising at least one pharmaceutical agent, and
wherein each of said plurality of polymer layers comprises a sintered layer in which the morphology of said pharmaceutical agent in said coating has not been modified, and
said first pharmaceutical agent is crystalline or semi-crystalline.
9. The pharmaceutical product of claim 8 , wherein said at least one polymer layer comprises a bioabsorbable polymer.
10. The pharmaceutical product of claim 8 , wherein said polymer of said at least one polymer layer is selected from PLA, PLGA, PGA, and Poly(dioxanone).
11. The pharmaceutical product of claim 8 , comprising five or more layers, as follows:
a first polymer layer;
a first pharmaceutical layer comprising said at least one pharmaceutical agent;
a second polymer layer;
a second pharmaceutical layer comprising a second pharmaceutical agent; and
a third polymer layer.
12. The pharmaceutical product of claim 8 , comprising four or more layers, as follows:
a first polymer layer;
a first pharmaceutical layer comprising said at least one pharmaceutical agent;
a second polymer layer; and
a second pharmaceutical layer comprising a second pharmaceutical agent.
13. The pharmaceutical product of claim 8 , wherein said pharmaceutical layer and said at least one polymer layer comprise alternate layers of pharmaceutical agent, or pharmaceutical agent and polymer, and layers of polymer without pharmaceutical agent.