Oral compositions and methods of use
Compositions that include from 0.1 wt-% to 8 wt-% of one or more compounds of formula (I) based on the total weight of the composition HOCH 2 —(CHOH) n —CH 2 NR 1 R 2 (I) wherein R 1 and R 2 are independently selected from the group consisting of a hydrogen atom, an alkyl group, C(O)R 3 , and SO 2 R 4 ; with R 3 and R 4 being independently selected from the group consisting of an alkyl group, an aryl group, and an aralkyl group; wherein n is an integer from about 2 to about 5; from 5 wt-% to 95 wt-% of one or more plant based oils based on the total weight of the composition; from 5 wt-% to 80 wt-% water based on the total weight of the composition and from 0.01 wt-% to 1 wt-% of one or more nonionic aromatic phenolic preservatives based on the total weight of the composition wherein the composition has a pH from 4.5 to 9.5, the composition is an emulsion, and the composition is edible.
1. A composition comprising:
one or more compounds of formula (I) present in an amount from 0.1 wt-% to 8 wt-% based on the total weight of the composition
HOCH 2 —(CHOH) n —CH 2 NR 1 R 2 (I),
wherein:
R 1 and R 2 are independently selected from the group consisting of hydrogen, an alkyl group, C(O)R 3 , and SO 2 R 4 ;
R 3 and R 4 being independently selected from the group consisting of an alkyl group, an aryl group, and an aralkyl group; and
n is an integer from 2 to 5;
one or more plant-based oils present in an amount from 75 wt-% to 95 wt-% of based on the total weight of the composition;
an aqueous phase comprising:
water,
wherein the aqueous phase is present in an amount no greater than 30 wt-% based on the total weight of the composition, and
one or more nonionic aromatic phenolic preservatives present in an amount from 0.01 wt-% to 1 wt-% based on the total weight of the composition
wherein:
the composition is characterized by a pH from 4.5 to 9.5,
the composition is water-in-oil emulsion, and
the composition is edible.
2. The composition according to claim 1 , wherein at least one of R 1 and R 2 is C(O)R 3 , and R 3 is selected from the group consisting of a C 7-9 alkyl group.
3. The composition according to claim 1 , wherein n is 4.
4. The composition according to claim 1 , wherein a compound of formula I is present in an amount from 1 to 2 wt-%.
5. The composition according to claim 2 , wherein R 3 is a C 8 alkyl group.
6. The composition according to claim 1 , wherein the one or more edible plant-based oils are selected from: sunflower oil, safflower oil, olive oil, coconut oil, palm oil, peanut oil, soybean oil, linseed oil, rapeseed oil, flaxseed oil, hempseed oil, cocoa butter, walnut oil, corn oil, grape seed oil, sesame oil, groundnut oil, wheat germ oil, cottonseed oil, fish oil, watermelon seed oil, lemon oil, orange oil, thistle oil, tomato seed oil, almond oil, perilla oil, canola oil, pistachio oil, hazelnut oil, camellia seed oil, shea nut oil, apricot kernel oil, oleic acid, and avocado oil.
7. The composition according to claim 1 , wherein the one or more nonionic aromatic phenolic preservative is selected from propyl paraben; thymol; a separate preservative mixture comprising 77-86%, benzyl alcohol, 8-15% salicylic acid, 3-5% glycerin and 1-4% sorbic acid; and a combination thereof.
8. The composition according to claim 1 , wherein the one or more nonionic aromatic phenolic preservative is present in an amount not greater than 0.8 wt-% based on the total weight of the composition.
9. The composition according to claim 1 , further comprising a sweetener, a humectant, a mineral salt, a buffering component, a flavorant, a preservative agent, or a combination thereof.
10. The composition according to claim 1 , further comprising aloe vera, folic acid, hyaluronic acid, octyl glucopyranoside, N-acetyl-D-glucosamine, N-acetyl-D-Galactosamine, D-glucosamine hydrochloride, D-glucosamine sulfate, D-glucamine, N-methyl-D-glucamine, N-ethyl-D-glucamine, N-octyl-D-glucamine, xylitol, sorbitol, erythritol, mannitol, glycine, nonanoic acid, ethyl caprylate, DMSO, ceramides, arginine, betaines or oxygenated glycerol triesters, vitamin E, vitamin B12, EDTA, cetyl pyridinium chloride, chlorhexidine, other antiseptics, or a combination thereof.
11. The composition according to claim 1 , further comprising a sweetener present in an amount from 1 wt-% to 20 wt-% based on the total weight of the composition.
12. The composition according to claim 1 , further comprising a humectant present in an amount from 2.5 wt-% to 40 wt-% based on the total weight of the composition.
13. The composition according to claim 1 , wherein the composition does not include any quaternary ammonium antimicrobial compounds.
14. The composition according to claim 1 , wherein the composition one or more of prevents, inhibits, disrupts, disperses, reduces, and controls the formation or maintenance of a biofilm in an area contacted with the composition.
15. The composition according to claim 1 , wherein the composition reduces hydration loss in an area contacted by the composition.
16. The composition according to claim 1 , wherein the composition increases lubricity or lubriciousness of an area contacted by the composition.
17. A method of reducing hydration loss in an oral tissue, the method comprising:
contacting an oral tissue with a composition according to claim 1 .
18. A method of increasing lubricity or lubriciousness in an oral tissue, the method comprising:
contacting an oral tissue with a composition according to claim 1 .
19. A method of mitigating the effects of xerostomia, dry mouth, or both, the method comprising:
contacting an oral tissue with a composition according to claim 1 .