Immunogenic compositions comprising
The present invention provides combination vaccines that comprise an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis , and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine. Moreover, the present invention also relates to a kit that comprises an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis , and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine.
1. A pharmaceutical composition comprising:
antigens consisting essentially of
a killed Lawsonia intracellularis bacterium and
a porcine circovirus antigen; and
a pharmaceutically acceptable carrier.
2. The pharmaceutical composition of claim 1 , wherein the pharmaceutically acceptable carrier is an adjuvant.
3. The pharmaceutical composition of claim 2 , wherein the adjuvant is a water-in-oil emulsion, an oil-in-water emulsion, or a water-in-oil-in-water emulsion.
4. A method for
administering to swine the pharmaceutical composition according to claim 1 .
5. The method of claim 4 , wherein the pharmaceutically acceptable carrier is an adjuvant.
6. The method of claim 5 , wherein the adjuvant is a water-in-oil emulsion, an oil-in-water emulsion, or a water-in-oil-in-water emulsion.
7. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition has between 5 to 5000 micrograms of the porcine circovirus antigen.
8. The method of claim 4 , wherein the pharmaceutical composition has between 5 to 5000 micrograms of the porcine circovirus antigen.
9. The method of claim 4 , wherein the pharmaceutical composition is administered in one dose.
10. The method of claim 4 , wherein the pharmaceutical composition is administered in multiple doses.
11. The method of claim 10 , wherein a first dose of the pharmaceutical composition is administered when the swine is about 2 to about 8 weeks of age.
12. The method of claim 11 , wherein a second dose of the pharmaceutical composition is administered about 1 to 4 weeks after the first dose.