Oxysterols and methods of use thereof
Compounds are provided according to Formula (I): Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein R 1 , R 2 , R 3 , R 6 , R 7 , R 8 , and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
1. A compound of Formula (III-A):
or a pharmaceutically acceptable salt thereof, wherein:
R 1 is C 1-6 alkyl; and
R 2 and R 3 are each independently substituted or unsubstituted methyl, substituted or unsubstituted ethyl, propyl, isopropyl, cyclopropyl, or butyl.
2. The compound of claim 1 , wherein R 1 is methyl, substituted C 1-6 alkyl selected from the group consisting of —CHF 2 , —CF 3 , —CH 2 OCH 3 , and —CH 2 OCH 2 CH 3 , ethyl, or isopropyl.
3. The compound of claim 2 , wherein R 1 is methyl or ethyl.
4. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
5. A pharmaceutical composition comprising a compound of claim 1 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
6. A method for modulating an NMDA receptor in a subject in need thereof, comprising administering to the subject in need thereof an effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the subject has a CNS-related condition.
7. The method according to claim 6 , wherein the CNS-related condition is an obsessive-compulsive disorder, posttraumatic stress disorder, social phobia, cognitive disorder (including Alzheimer's disease and other forms of dementia), eating disorder, schizophrenia, autism spectrum disorders, pain, anti-NMDA receptor encephalitis, Huntington's disease, or Parkinson's disease.