Highly active anti-neoplastic and anti-proliferative agents
This invention is in the area of improved compounds and methods for treating selected cancers and hyperproliferative disorders.
1. A method of treating T-cell leukemia in a human in need thereof comprising administering to the host an effective amount of a compound having the structure:
or a pharmaceutically acceptable salt thereof
wherein the T-cell leukemia is acute lymphoblastic leukemia (ALL).
2. The method of claim 1 , wherein the compound, or its pharmaceutically acceptable salt thereof, is administered in combination with a second active agent.
3. A method of treating T-cell leukemia in a human in need thereof comprising administering to the host an effective amount of a compound having the structure:
or a pharmaceutically acceptable salt thereof
wherein the T-cell leukemia is acute lymphoblastic leukemia.
4. The method of claim 3 , wherein the compound, or its pharmaceutically acceptable salt thereof, is administered in combination with a second active agent.
5. A method of treating T-cell lymphoma in a human in need thereof comprising administering to the host an effective amount of a compound having the structure:
or a pharmaceutically acceptable salt thereof
wherein the T-cell lymphoma is lymphoblastic lymphoma.
6. The method of claim 5 , wherein the compound, or its pharmaceutically acceptable salt thereof, is administered in combination with a second active agent.
7. A method of treating T-cell lymphoma in a human in need thereof comprising administering to the host an effective amount of a compound having the structure:
or a pharmaceutically acceptable salt thereof
wherein the T-cell lymphoma is lymphoblastic lymphoma.
8. The method of claim 7 , wherein the compound, or its pharmaceutically acceptable salt thereof, is administered in combination therapy with a second active agent.