IP Library Granted Patent US 10,507,221
Granted Patent B2
US 10,507,221 · App. 16/229,288 · Granted Dec 17, 2019

Compositions and methods for the treatment of allergy

Inventors: Rose L. Szabady (Cambridge, MA); Bernat Olle (Cambridge, MA); Bruce Roberts (Sudbury, MA)
Assignee: Vedanta Biosciences, Inc.
A61K35/74A61K9/0053A61K9/19A61K9/48A61P37/08
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Quick Facts
Patent No.
US 10,507,221
App. No.
16/229,288
Granted
Dec 17, 2019
Kind
B2
Abstract

Provided herein are compositions and methods for the treatment of allergy, such as food allergy. Also provided herein are compositions and methods for modulating an immune response associated with allergy and/or inducing immune tolerance or desensitization to an allergy, such as a food allergy.

Claims (16)

1. A method of treating a food allergy, comprising

orally administering to a subject in need thereof a therapeutically effective amount of a composition comprising a purified bacterial mixture consisting of 7 bacterial strains each comprising one of 16S rDNA sequences having at least 99.5% sequence identity to SEQ ID NOs: 1-5, 7, and 8, wherein there is 1 strain comprising each of the 16S rDNA sequences having at least 99.5% sequence identity to SEQ ID NOs: 1-5, 7, and 8.

2. The method of claim 1 , wherein the subject is administered an antibiotic prior to administration of the composition.

3. The method of claim 2 , wherein the antibiotic is vancomycin.

4. The method of claim 1 , wherein the food allergy is selected from the group consisting of a nut allergy, a fish allergy, a wheat allergy, a milk allergy, a peanut allergy, a tree nut allergy, a shellfish allergy, a soy allergy, a seed allergy, a sesame seed allergy, and an egg allergy.

5. The method of claim 1 , wherein the food allergy is a peanut allergy.

6. The method of claim 1 , wherein one or more of the bacterial strains are in spore form.

7. The method of claim 1 , wherein one or more of the bacterial strains are lyophilized.

8. The method of claim 1 , wherein all of the bacterial strains are lyophilized.

9. The method of claim 1 , wherein one or more of the bacterial strains are spray-dried.

10. The method of claim 1 , wherein all of the bacterial strains are spray-dried.

11. The method of claim 1 , wherein the bacterial strains originate from more than one human donor.

12. The method of claim 1 , wherein the composition is in the form of a capsule.

13. The method of claim 1 , wherein the composition further comprises one or more enteric polymers.

14. The method of claim 1 , wherein the composition further comprises one or more adjuvants.

15. The method of claim 3 , wherein vancomycin is administered in 4 doses of 125 mg vancomycin per day for 5 days.

Assignments (4)
RELEASE OF SECURITY INTEREST Recorded Apr 24, 2023
From: OXFORD FINANCE LLC
To: VEDANTA BIOSCIENCES, INC.
Reel/Frame 063440/0569 →
SECURITY INTEREST Recorded Apr 21, 2023
From: VEDANTA BIOSCIENCES, INC.
To: ANKURA TRUST COMPANY, LLC, AS COLLATERAL TRUSTEE
Reel/Frame 063406/0052 →
SECURITY INTEREST Recorded Dec 12, 2022
From: VEDANTA BIOSCIENCES, INC.
To: OXFORD FINANCE LLC
Reel/Frame 062115/0411 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 15, 2019
From: SZABADY, ROSE L.; OLLE, BERNAT; ROBERTS, BRUCE
To: VEDANTA BIOSCIENCES, INC.
Reel/Frame 049181/0575 →
Continuity (5)
Continuation PCTUS2018060187 · Nov 9, 2018
Provisional Application 62721786 · Aug 23, 2018
Provisional Application 62637355 · Mar 1, 2018
Provisional Application 62583777 · Nov 9, 2017
Related Publication 20190134107A1 · May 9, 2019
Cited By (1)
US 12,582,679