IL-17 Receptor A antigen binding proteins
The present invention relates to IL-17 Receptor A (IL-17RA or IL-17R) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases mediated by IL-17 Receptor A activation by one or more IL-17 ligands. The present invention relates to the identification of neutralizing determinants on IL-17 Receptor A (IL-17RA or IL-17R) and antibodies that bind thereto. Aspects of the invention also include antibodies that compete for binding with the IL-17RA neutralizing antibodies described herein.
1. A human monoclonal antibody that specifically binds to IL-17 receptor A (IL-17RA), or an antigen-binding fragment thereof, which antibody comprises: a light chain CDR1 of SEQ ID NO:248, CDR2 of SEQ ID NO:249, and CDR3 of SEQ ID NO:250; and a heavy chain CDR1 of SEQ ID NO:170, CDR2 of SEQ ID NO:171, and CDR3 of SEQ ID NO:172.
2. The human monoclonal antibody of claim 1 , which comprises a light chain variable domain amino acid sequence of SEQ ID NO: 48 and a heavy chain variable domain amino acid sequence of SEQ ID NO: 22.
3. A composition comprising the human monoclonal antibody of claim 1 and a pharmaceutically acceptable carrier.