Bone repair composition and kit
A biocompatible material for bone repair is described. The bone repair composition includes a mixture of a type I collagen, a type I collagen-glycosaminoglycan coprecipitate, tricalcium phosphate; and bioactive glass. Methods of using the composition for bone repair, and a kit for the bone repair composition are also described.
1. A bone repair composition, comprising a mixture of:
a type I collagen;
a type I collagen-glycosaminoglycan coprecipitate comprising glycosaminoglycan (GAG);
tricalcium phosphate; and
bioactive glass, wherein
a weight ratio of the type I collagen to the type I collagen-glycosaminoglycan coprecipitate ranges from 0.01 to 2.0.
2. The composition of claim 1 , wherein the tricalcium phosphate comprises particles having a size from 500 to 1400 microns.
3. The composition of claim 1 , wherein the bioactive glass comprises particles having a size from 500 to 1000 microns.
4. The composition of claim 1 , wherein the bioactive glass develops a hydroxyapatite surface layer upon implantation within a subject.
5. The composition of claim 1 , wherein the composition exhibits a color change upon sterilization.
6. The composition of claim 1 , wherein the bone repair composition is configured as a rectangular strip.
7. The composition of claim 1 , wherein the glycosaminoglycan is chondroitin 4 sulfate or chondroitin 6 sulfate.
8. The composition of claim 1 , wherein the bioactive glass is present at 15% to 25% by weight.
9. The composition of claim 1 , wherein the tricalcium phosphate is present at 75% to 85% by weight.
10. The composition of claim 1 , wherein the combined weight percent of the type I collagen and the type I collagen-glycosaminoglycan coprecipitate is from 1% to 5%.
11. The composition of claim 1 , wherein the type I collagen comprises fine flakes or particles obtained by milling collagen through a 20 mesh screen.
12. A method of repairing a bone defect, comprising administering the composition of claim 1 to the site of the bone defect.
13. The method of claim 12 , wherein the composition is hydrated before administering the bone repair composition to the site of the bone defect.
14. The method of claim 13 , wherein the bone repair composition is hydrated with autologous blood.
15. The method of claim 12 , wherein the bone defect is, or is the result of, a simple fracture, a compound fracture, external fixation, internal fixation, joint reconstruction, arthroplasty, degenerative disc disease, avascular osteonecrosis, osteosarcoma fracture, fracture non-unions, spinal fusion, disc augmentation, or bone regeneration in orthopedic implants.
16. A bone repair kit, comprising:
the bone repair composition of claim 1 ; and
packaging for holding the bone repair composition.
17. The bone repair kit of claim 16 , further comprising instructions for repairing a bone defect.
18. The bone repair kit of claim 16 , wherein the bone repair composition is configured as a rectangular strip.
19. The bone repair kit of claim 16 , wherein the packaging includes a tray configured to fit the shape of the bone repair composition.
20. The bone repair kit of claim 19 , wherein the tray includes one or more grip regions to facilitate access to the bone repair composition.
21. The bone repair kit of claim 19 , wherein the tray includes a support region that holds the bone repair composition above the bottom of the tray.
22. The bone repair kit of claim 19 , wherein the kit includes a cover that can be sealed with a sheet to hold the tray.
23. The bone repair kit of claim 16 , wherein the package comprises high density polyethylene.