ABSORBANT AND REFLECTING BIOCOMPATIBLE DYES FOR HIGHLY ACCURATE MEDICAL IMPLANTS
A light-polymerizable composition for additive manufacturing of resorbable scaffolds and implants comprising a biocompatible resin. The biocompatible resin includes a combination of photo-initiators or a dye-initiator package tailored to manufacture implants with the desired physical and chemical properties. A dye or other constituent controls between layer (z) resolution of the manufactured part built in an additive manufacturing device. A light absorber or other constituent controls within layer (x-y) resolution of the manufactured part.
1 . A dye-initiator package for a resin composition used in the additive manufacturing of resorbable implants comprising, a first dye which limits the transmission of light that activates a photo-initiator, a photo-initiator and a light absorber which absorbs light reflected from the first dye, wherein the resin comprises at least one polymer and at least one solvent.
2 . The dye-initiator package of claim 1 wherein the first dye is TiO2.
3 . The dye-initiator package of claim 2 , wherein the photo-initiator is an acylphosphine oxide.
4 . The dye-initiator package of claim 3 wherein the photo-initiator is Bis(2,4,6-trimethylbenzoyl)-phenylphosphineoxide (BAPO).
5 . The dye-initiator package of claim 3 wherein the light absorber is a benzophenone.
6 . The dye-initiator package of claim 5 wherein the benzophenone is selected from the group consisting of: 2,4-dihydroxybenzophenone, 2,2′,4,4′-tetrahydroxybenzophenone, sulisobenzone, sulixobenzone sodium, 2,2′-dihydroxy-4,4′-dimethyoxybenzophenone, 5-chloro-2-hydroxybenzophenone, dioxybenzone, sodium 2,2′-dihydroxy-4,4′-dimethoxybenzophenone-5,5′-disulfonate, 2-hydroxy-4-methoxy-4′-methyl-benzophenone, benzophenone-2, benzophenone-6, octabenzone, and 2-Hydroxy-4-methoxybenzophenone (oxybenzone).
7 . The dye-initiator package of claim 3 , wherein the light absorber is oxybenzone (2-Hydroxy-4-m ethoxybenzophenone).
8 . The dye-initiator package of claim 3 wherein the light absorber is avobenzone.
9 . The dye-initiator package of claim 1 , wherein the first dye is Bis(.eta.5-2,4-cylcopentadien-1-yl)-bis(2,6-difluoro-3-(1H-pyrrol-1-yl)-phenyl) titanium.
10 . The dye-initiator package of claim 9 , wherein the photo-initiator is Bis(2,4,6-trimethylbenzoyl)-phenylphosphineoxide (BAPO).
11 . The dye-initiator package of claim 10 , wherein the light absorber is oxybenzone (2-Hydroxy-4-m ethoxybenzophenone).
12 . The dye-initiator package of claim 2 wherein the amount of TiO2 is 0.1 to 5.0% by weight of the polymer and solvent.
13 . The dye-initiator package of claim 4 wherein the amount of BAPO is 0.1 to 5.0% by weight of the polymer and solvent.
14 . The dye-initiator package of claim 7 wherein the amount of oxybenzone by weight of the polymer and solvent is about 25 to 35%.
15 . The dye-initiator package of claim 9 wherein the amount of Bis(.eta.5-2,4-cylcopentadien-1-yl)-bis(2,6-difluoro-3-(1H-pyrrol-1-yl)-phenyl) titanium by weight of the polymer and solvent is about 0.1 to 5.0%.
16 . The dye-initiator package of claim 10 wherein the amount of BAPO by weight of the polymer and solvent is about 0.1 to 5.0%.
17 . The dye-initiator package of claim 11 wherein the amount of oxybenzone by weight of the polymer and solvent is about 0.1 to 5.0%.
18 . A photo-initiator package for a light polymerizable composition for use in tissue engineering applications comprising: a first photo-initiator and a second photo-initiator wherein the first photo-initiator cures the composition when exposed to a first light source in an additive manufacturing device and the second photo-initiator limits the transmission of light that activates the first photo-initiator in the additive manufacturing device, and wherein the second photo-initiator is activated when exposed to a second light source used to post-cure the composition, wherein the light polymerizable composition comprises at least one polymer and at least one solvent.
19 . The photo-initiator package of claim 18 wherein one or both of the first and second photo-initiators are an acylphosphine oxide.
20 . The photo-initiator package of claim 19 wherein the first photo-initiator is Bis(2,4,6-trimethylbenzoyl)-phenylphosphineoxide (BAPO).
21 . The photo-initiator package of claim 19 wherein the second photo-initiator is Bis(.eta.5-2,4-cylcopentadien-1-yl)-bis(2,6-difluoro-3-(1H-pyrrol-1-yl)-phenyl) titanium.
22 . The photo-initiator package of claim 19 wherein the amount of the first photo-initiator and the second photo-initiator are about 0.1 to 5.0% by weight of the polymer and solvent.
23 . The photo-initiator package of claim 21 wherein the amount of Bis(.eta.5-2,4-cylcopentadien-1-yl)-bis(2,6-difluoro-3-(1H-pyrrol-1-yl)-phenyl) titanium by weight of the polymer and solvent is about 0.1 to 5.0%.
24 . The photo-initiator package of claim 22 wherein the amount of BAPO by weight of the polymer and solvent is about 0.1 to 5.0%.
25 - 39 . (canceled)