Tunable nitric oxide-releasing macromolecules having multiple nitric oxide donor structures
View Patent ↗Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.
1. A nitric oxide (NO)-releasing co-condensed silica macromolecule comprising:
a co-condensed silica network comprising N-diazeniumdiolate functionalized N-ethylaminoisobutyltrimethoxysilane (EAiB3), N-diazeniumdiolate functionalized [3-(methylamino)propyl]trimethoxysilane (MAP3), and tetraethyl orthosilicate (TEOS).
2. The NO-releasing co-condensed silica macromolecule of claim 1 , wherein EAiB3 and MAP3 are present in a ratio from about 1:1 to about 3:1 (EAiB3:MAP3).
3. The NO-releasing co-condensed silica macromolecule of claim 1 , wherein EAiB3 and MAP3 are present in a ratio of about 1:1 (EaiB3:MAP3).
4. The NO-releasing co-condensed silica macromolecule of claim 1 , wherein EaiB3 and MAP3 are present in a ratio of about 2:1 (EaiB3:MAP3).
5. The NO-releasing co-condensed silica macromolecule of claim 1 , wherein EaiB3 and MAP3 are present in a ratio of about 3:1 (EaiB3:MAP3).
6. The NO-releasing co-condensed silica macromolecule of claim 1 , wherein EaiB3 and/or MAP3 comprise a Na + , K + , Cs + , Li + , NH 4 + , or other quaternary ammonium cation.
7. The NO-releasing co-condensed silica macromolecule of claim 1 , wherein EaiB3 and/or MAP3 comprise a sodium cation.
8. The NO-releasing co-condensed silica macromolecule of claim 1 , wherein EaiB3 and/or MAP3 comprise a potassium cation.
9. The NO-releasing co-condensed silica macromolecule of claim 1 , wherein EaiB3 and/or MAP3 comprise a lithium cation.
10. The NO-releasing co-condensed silica macromolecule of claim 1 , wherein TEOS is anionic.
11. A nitric oxide (NO)-releasing co-condensed silica macromolecule comprising:
a co-condensed silica network comprising N-diazeniumdiolate functionalized aminoethylaminopropyl trimethoxysilane (AEAP3), N-diazeniumdiolate functionalized [3-(methylamino)propyl]trimethoxysilane (MAP3), and tetra methyl orthosilicate (TEOS).
12. The NO-releasing co-condensed silica macromolecule of claim 1 , wherein AEAP3 and MAP3 are present in a ratio from about 1:1 to about 3:1 (AEAP3:MAP3).
13. The NO-releasing co-condensed silica macromolecule of claim 1 , wherein AEAP3 and MAP3 are present in a ratio of about 1:1 (AEAP3:MAP3).
14. The NO-releasing co-condensed silica macromolecule of claim 1 , wherein AEAP3 and MAP3 are present in a ratio of about 2:1 (AEAP3:MAP3).
15. The NO-releasing co-condensed silica macromolecule of claim 1 , wherein AEAP3 and MAP3 are present in a ratio of about 3:1 (AEAP3:MAP3).
16. The NO-releasing co-condensed silica macromolecule of claim 1 , wherein AEAP3 and/or MAP3 comprise a Na + , K + , Cs + , Li + , NH 4 + , or other quaternary ammonium cation.
17. The NO-releasing co-condensed silica macromolecule of claim 1 , wherein AEAP3 and/or MAP3 comprise a sodium cation.
18. The NO-releasing co-condensed silica macromolecule of claim 1 , wherein AEAP3 and/or MAP3 comprise a potassium cation.
19. The NO-releasing co-condensed silica macromolecule of claim 1 , wherein AEAP3 and/or MAP3 comprise a lithium cation.
20. A nitric oxide (NO)-releasing co-condensed silica macromolecule comprising:
a co-condensed silica network comprising N-diazeniumdiolate functionalized aminoethylaminopropyl trimethoxysilane (AEAP3), N-diazeniumdiolate functionalized [3-(methylamino)propyl]trimethoxysilane (MAP3), and tetraethyl orthosilicate (TMOS).