IP Library Granted Patent US 11,154,273
Granted Patent B2
US 11,154,273 · App. 16/246,419 · Granted Oct 26, 2021

Systems and methods for vascular mapping

Inventors: Michael O'Brien (Los Angeles, CA); Mina Ranjbaran (Los Angeles, CA); Leo Petrossian (Los Angeles, CA); Robert Hamilton (Los Angeles, CA); Shankar Radhakrishnan (Los Angeles, CA); Corey M. Thibeault (Los Angeles, CA); Samuel G. Thorpe (Los Angeles, CA); Nicolas Canac (Los Angeles, CA)
Assignee: NovaSignal Corp.
A61B8/4218A61B8/06A61B8/0808A61B8/0891A61B8/4245A61B8/4444A61B8/483A61B8/486A61B8/488A61B8/5253A61B5/4064A61B8/429A61B8/4483A61B8/5207A61B8/5246A61B8/5292A61B34/30
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Quick Facts
Patent No.
US 11,154,273
App. No.
16/246,419
Granted
Oct 26, 2021
Kind
B2
Abstract

Systems, apparatuses, methods, and non-transitory computer-readable media for mapping a section of a vasculature of a subject are described herein, including moving a probe to a first position adjacent the section of the vasculature; transmitting, by the probe, a first ultra-sound beam into a first portion of the section of the vasculature through the body of the subject; receiving first ultra-sound data including at least one imaging parameter; moving the probe to a second position at the body of the subject adjacent the section of the vasculature and different from the first position; transmitting, by the probe, a second ultrasound beam into a second portion of the section of the vasculature through the body of the subject; receiving second ultrasound data including the at least one imaging parameter; and constructing a map of the section of the vasculature based on the first ultrasound data and the second ultrasound data.

Claims (52)

1. A method for mapping a section of a vasculature of a subject, comprising:

moving a probe, by a robot connected to the probe, to a first position at a body of the subject adjacent the section of the vasculature;

transmitting, by the probe, a first ultrasound beam into a first portion of the section of the vasculature through the body of the subject, the first ultrasound beam simultaneously insonating a first plurality of depths;

receiving first ultrasound data including at least one imaging parameter of the first portion simultaneously from one or more of the first plurality of depths of the first ultrasound beam;

moving the probe, by the robot connected to the probe, to a second position at the body of the subject adjacent the section of the vasculature, the second position different from the first position;

transmitting, by the probe, a second ultrasound beam into a second portion of the section of the vasculature through the body of the subject, the second ultrasound beam simultaneously insonating a second plurality of depths;

receiving second ultrasound data including the at least one imaging parameter of the second portion based on the second ultrasound beam;

tracking positional information of the probe;

determining that ultrasound data acquired is enough for constructing a map of the section of the vasculature, wherein the ultrasound data comprises the first ultrasound data and the second ultrasound data; and

in response to determining that the ultrasound data acquired is enough for constructing the map, constructing the map of the section of the vasculature based on the first ultrasound data and the second ultrasound data, wherein constructing the map comprises aligning the first ultrasound data and the second ultrasound data with the positional information of the probe based on the first plurality of depths and the second plurality of depths.

2. The method of claim 1 , wherein the section of the vasculature comprises the circle of Willis of the subject.

3. The method of claim 1 , wherein the at least one imaging parameter comprises presence and vector direction of blood flow.

4. The method of claim 1 , wherein the first and second portions of the section of the vasculature are the same and the first and second ultrasound beams insonate the first and second portions at different angles.

5. The method of claim 1 , wherein the first and second portions of the section of the vasculature are different.

6. The method of claim 5 , wherein the first and second portions of the section of the vasculature overlap each other.

7. The method of claim 1 , wherein the first and second ultrasound beams comprise a predetermined length.

8. The method of claim 7 , wherein the predetermined length is about 60 millimeters.

9. The method of claim 1 , wherein the one or more of the first plurality of depths comprise at least two of the first plurality of depths.

10. The method of claim 1 , wherein constructing the map of the section of the vasculature comprises generating coordinates of the first and second portions of the section of the vasculature in three-dimensional space.

11. The method of claim 10 , wherein the coordinates of the first and second portions of the section of the vasculature are based on a plurality of insonated depths where the first and second ultrasound beams overlap the first and second portions.

12. The method of claim 10 , wherein constructing the map of the section of the vasculature further comprises connecting the coordinates of the first and second portions of the section of the vasculature in three-dimensional space.

13. The method of claim 1 , wherein the first and second ultrasound beams comprise transcranial Doppler ultrasound.

14. The method of claim 1 , wherein the probe comprises a single ultrasound transducer.

15. The method of claim 1 , wherein the robot is configured to move the probe in five degrees of freedom.

16. The method of claim 1 , wherein the robot moves the probe to the second position after transmitting the first ultrasound beam.

17. The method of claim 1 , wherein determining that the ultrasound data acquired is enough for constructing the map comprises one of:

determining a number of ultrasound insonation;

determining an amount of ultrasound data;

determining an number of movements of the probe, wherein the movements comprise moving the probe to the first position and moving the probe to the second position; or

determining an amount of time lapsed.

18. A tool for mapping a section of a vasculature of a subject, comprising:

a probe; and

a processing circuit configured to:

move the probe, by a robot connected to the probe, to a first position at a body of the subject adjacent the section of the vasculature;

transmit, by the probe, a first ultrasound beam into a first portion of the section of the vasculature through the body of the subject, the first ultrasound beam simultaneously insonating a first plurality of depths;

receive first ultrasound data including at least one imaging parameter of the first portion simultaneously from one or more of the first plurality of depths of the first ultrasound beam;

move the probe, by the robot connected to the probe, to a second position at the body of the subject adjacent the section of the vasculature, the second position different from the first position;

transmit, by the probe, a second ultrasound beam into a second portion of the section of the vasculature through the body of the subject, the second ultrasound beam simultaneously insonating a second plurality of depths;

receive second ultrasound data including the at least one imaging parameter of the second portion simultaneously from one or more of the second plurality of depths of the second ultrasound beam;

track positional information of the probe;

determine that ultrasound data acquired is enough for constructing a map of the section of the vasculature, wherein the ultrasound data comprises the first ultrasound data and the second ultrasound data; and

in response to determining that the ultrasound data acquired is enough for constructing the map, construct the map of the section of the vasculature based on the first ultrasound data and the second ultrasound data, wherein constructing the map comprises aligning the first ultrasound data and the second ultrasound data with the positional information of the probe based on the first plurality of depths and the second plurality of depths.

19. A non-transitory computer-readable medium having computer-readable instructions such that, when executed by a processor, maps a section of a vasculature of a subject by:

moving a probe, by a robot connected to the probe, to a first position at a body of the subject adjacent the section of the vasculature;

transmitting, by the probe, a first ultrasound beam into a first portion of the section of the vasculature through the body of the subject, the first ultrasound beam simultaneously insonating a first plurality of depths;

receiving first ultrasound data including at least one imaging parameter of the first portion simultaneously from one or more of the first plurality of depths of the first ultrasound beam;

moving the probe, by the robot connected to the probe, to a second position at the body of the subject adjacent the section of the vasculature, the second position different from the first position;

transmitting, by the probe, a second ultrasound beam into a second portion of the section of the vasculature through the body of the subject, the second ultrasound beam simultaneously insonating a second plurality of depths;

receiving second ultrasound data including the at least one imaging parameter of the second portion simultaneously from one or more of the second plurality of depths of the second ultrasound beam;

tracking positional information of the probe;

determining that ultrasound data acquired is enough for constructing a map of the section of the vasculature, wherein the ultrasound data comprises the first ultrasound data and the second ultrasound data; and

in response to determining that the ultrasound data acquired is enough for constructing the map, constructing the map of the section of the vasculature based on the first ultrasound data and the second ultrasound data, wherein constructing the map comprises aligning the first ultrasound data and the second ultrasound data with the positional information of the probe based on the first plurality of depths and the second plurality of depths.

Assignments (8)
DEFAULT Recorded Mar 5, 2024
From: NOVASIGNAL CORP.
To: AVENUE VENTURE OPPORTUNITIES FUND, L.P.
Reel/Frame 066741/0678 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 10, 2023
From: AVENUE VENTURE OPPORTUNITIES FUND, L.P.
To: NEURASIGNAL, INC.
Reel/Frame 064238/0383 →
STATEMENT OF FORECLOSURE Recorded Jul 5, 2023
From: NOVASIGNAL CORP.
To: AVENUE VENTURE OPPORTUNITIES FUND, L.P.
Reel/Frame 064206/0484 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 5, 2023
From: AVENUE VENTURE OPPORTUNITIES FUND, L.P.
To: NEURASIGNAL, INC.
Reel/Frame 064155/0787 →
SECURITY INTEREST Recorded Jul 5, 2023
From: NEURASIGNAL, INC.
To: AVENUE CAPITAL MANAGEMENT II, L.P.
Reel/Frame 064155/0854 →
SECURITY INTEREST Recorded Dec 18, 2021
From: NOVASIGNAL CORP.
To: AVENUE VENTURE OPPORTUNITIES FUND, L.P.
Reel/Frame 058425/0481 →
CHANGE OF NAME Recorded Jun 1, 2021
From: NEURAL ANALYTICS, INC.
To: NOVASIGNAL CORP.
Reel/Frame 056447/0663 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 16, 2019
From: O'BRIEN, MICHAEL; RANJBARAN, MINA; PETROSSIAN, LEO; HAMILTON, ROBERT; RADHAKRISHNAN, SHANKAR; THIBEAULT, COREY M.; THORPE, SAMUEL G.; CANAC, NICOLAS
To: NEURAL ANALYTICS, INC.
Reel/Frame 050392/0780 →
Cited By (2)
US 12,390,191 US 12,440,974