Early warning of LVAD thrombus formation
A method of determining an adverse event within a patient having an implantable blood pump including calculating a plurality of power consumption trends of the blood pump during a plurality of time periods using a low-pass filter, determining a plurality of power trend differences between the plurality of power consumption trends, calculating a total amount of the plurality of power trend differences during a time interval, and generating an alarm when the total amount of the plurality of power trend differences exceeds a pre-determined threshold.
1. A method of determining an adverse event within a patient having an implantable blood pump, the method comprising:
calculating a plurality of power consumption trends of the blood pump during a plurality of time periods using a first low-pass filter and a second low-pass filter different than the first low-pass filter, calculating the plurality of power consumption trends includes calculating a short-term trend using the first low-pass filter and calculating a long-term trend using the second low-pass filter, the second low-pass filter having a cutoff frequency lower than a cutoff frequency of the first low-pass filter, the cutoff frequency of the first low-pass filter is a first optimized constant between 50 to 150 microHertz and the cutoff frequency of the second low-pass filter is a second optimized constant between 0.5 to 1.0 microHertz;
determining a plurality of power trend differences between the plurality of power consumption trends;
calculating a total amount of the plurality of power trend differences during a time interval; and
generating an alarm when the total amount of the plurality of power trend differences exceeds a pre-determined threshold.
2. The method of claim 1 , further comprising calculating the pre-determined threshold using a percentage of at least one of the plurality of power consumption trends.
3. The method of claim 1 , further comprising calculating the total amount of the plurality of power trend differences during the time interval using an integrator, the time interval being between 5 to 25 hours.
4. The method of claim 3 , further comprising calculating the total amount of the plurality of power trend differences during the time interval using an integrator, the time interval being a 24-hour time interval.
5. The method of claim 1 , further comprising:
calculating a high-power threshold using at least one of the plurality of power consumption trends;
calculating a real-time power value of the blood pump; and
generating an alarm when the real-time power value exceeds the high-power threshold.