Augmented biocontainment materials and augmented biocontainment enclosures
A biocontainment vessel includes a vessel structure including a structural composition and an enhancement composition associated with the structural composition. The enhancement composition includes a co-polymer. The co-polymer is a poly(glycerol sebacate) or a poly(glycerol sebacate urethane). The enhancement composition may also include an augmentation agent associated with the co-polymer. The enhancement composition is located with respect to the structural composition such that the enhancement composition benefits biological cells contained in the biocontainment vessel. A composition includes a co-polymer and an augmentation agent contained by the co-polymer. A method of containing biological cells includes placing the biological cells in an augmented biocontainment vessel and storing them in the augmented biocontainment vessel under predetermined conditions. An augmented substrate includes a substrate and an enhancement composition coating a surface of the substrate.
1. A biocontainment vessel comprising:
a vessel structure comprising:
a structural composition; and
an enhancement composition associated with the structural composition, the enhancement composition comprising a co-polymer selected from the group consisting of a poly(glycerol sebacate) and a poly(glycerol sebacate urethane) and an augmentation agent physically mixed with or chemically attached to the co-polymer, wherein the augmentation agent is selected from the group consisting of a 2-3-diphosphoglycerate scavenger, a composition protecting against hemoglobin scavenging of nitrous oxide, an affinity composition for toxins, a fiber extrudate, a paramagnetic material, a lactic acid scavenger, a cell preservation composition, a sanitation composition, a surface passivation composition, and combinations thereof.
2. The biocontainment vessel of claim 1 , wherein the structural composition comprises polyvinyl chloride.
3. The biocontainment vessel of claim 1 , wherein the enhancement composition is located on a surface of the structural composition on a containment side of the vessel structure.
4. The biocontainment vessel of claim 3 further comprising an inner film layer on a surface of the enhancement composition on a containment side of the vessel structure.
5. The biocontainment vessel of claim 1 , wherein the enhancement composition is a plasticizer mixed with the structural composition.
6. The biocontainment vessel of claim 1 , wherein the co-polymer is poly(glycerol sebacate).
7. The biocontainment vessel of claim 1 , wherein the co-polymer is poly(glycerol sebacate urethane).
8. The biocontainment vessel of claim 1 , wherein the enhancement composition is located with respect to the structural composition such that the augmentation agent benefits biological cells contained in the biocontainment vessel.
9. A method of containing biological cells, the method comprising:
placing the biological cells in the augmented biocontainment vessel of claim 1 ; and
storing the biological cells in the augmented biocontainment vessel under predetermined conditions.
10. The method of claim 9 , wherein the co-polymer is poly(glycerol sebacate).
11. The method of claim 9 , wherein the co-polymer is poly(glycerol sebacate urethane).
12. The method of claim 9 , wherein the enhancement composition is located with respect to the structural composition such that the augmentation agent benefits the biological cells contained in the biocontainment vessel.
13. A composition comprising:
a co-polymer selected from the group consisting of a poly(glycerol sebacate) and a poly(glycerol sebacate urethane); and
an augmentation agent physically mixed with or chemically attached to the co-polymer, wherein the augmentation agent is selected from the group consisting of a 2-3-diphosphoglycerate scavenger, a composition protecting against hemoglobin scavenging of nitrous oxide, an affinity composition for toxins, a fiber extrudate, a paramagnetic material, a lactic acid scavenger, a cell preservation composition, a sanitation composition, a surface passivation composition, and combinations thereof.
14. The composition of claim 13 , wherein the co-polymer is poly(glycerol sebacate).
15. The composition of claim 13 , wherein the co-polymer is poly(glycerol sebacate urethane).
16. The composition of claim 13 , wherein the augmentation agent is physically mixed with the co-polymer.
17. The composition of claim 13 , wherein the augmentation agent is chemically attached to the co-polymer.
18. An augmented substrate comprising:
a substrate; and
an enhancement composition coating a surface of the substrate, the enhancement composition comprising a co-polymer selected from the group consisting of a poly(glycerol sebacate) and a poly(glycerol sebacate urethane) and an augmentation agent physically mixed with or chemically attached to the co-polymer, wherein the augmentation agent is selected from the group consisting of a 2-3-diphosphoglycerate scavenger, a composition protecting against hemoglobin scavenging of nitrous oxide, an affinity composition for toxins, a fiber extrudate, a paramagnetic material, a lactic acid scavenger, a cell preservation composition, a sanitation composition, a surface passivation composition, and combinations thereof.
19. The composition of claim 13 , wherein the augmentation agent comprises a 2-3-diphosphoglycerate scavenger.
20. The composition of claim 13 , wherein the augmentation agent comprises a composition protecting against hemoglobin scavenging of nitrous oxide.
21. The composition of claim 13 , wherein the augmentation agent comprises an affinity composition for toxins.
22. The composition of claim 13 , wherein the augmentation agent comprises a fiber extrudate.
23. The composition of claim 13 , wherein the augmentation agent comprises a paramagnetic material.
24. The composition of claim 13 , wherein the augmentation agent comprises a lactic acid scavenger.
25. The composition of claim 13 , wherein the augmentation agent comprises a cell preservation composition.
26. The composition of claim 13 , wherein the augmentation agent comprises a sanitation composition.
27. The composition of claim 13 , wherein the augmentation agent comprises a surface passivation composition.