Aerosolized fluoroquinolones and uses thereof
Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
1. A method of treating a bacterial lung infection, comprising administering a pharmaceutical aerosol for nasal, sinunasal or pulmonary administration comprising a dispersed liquid phase and a continuous gas phase, wherein the dispersed liquid phase:
(a) consists essentially of aqueous droplets comprising an active compound comprising levofloxacin, and at least one excipient comprising a divalent metal ion;
(b) has a mass median diameter from about 1 to about 5 μm; and
(c) has a droplet size distribution exhibiting a geometrical standard deviation less than or equal to 3.0 μm.
2. The method of claim 1 , wherein the lung infection is caused by one or more of the following bacteria: Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas acidovorans, Pseudomonas alcaligenes, Pseudomonas putida, Stenotrophomonas maltophilia, Aeromonas hydrophilia, Escherichia coli, Citrobacter freundii, Salmonella typhimurium, Salmonella typhi, Salmonella paratyphi, Salmonella enteritidis, Shigella dysenteriae, Shigella flexneri, Shigella sonnei, Enterobacter cloacae, Enterobacter aerogenes, Klebsiella pneumoniae, Klebsiella oxytoca, Serratia marcescens, Morganella morganii, Proteus mirabilis, Proteus vulgaris, Providencia alcalifaciens, Providencia rettgeri, Providencia stuartii, Acinetobacter calcoaceticus, Acinetobacter haemolyticus, Yersinia enterocolitica, Yersinia pestis, Yersinia pseudotuberculosis, Yersinia intermedia, Bordetella pertussis, Bordetella parapertussis, Bordetella bronchiseptica, Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus haemolyticus, Haemophilus parahaemolyticus, Haemophilus ducreyi, Pasteurella multocida, Pasteurella haemolytica, Helicobacter pylori, Campylobacter fetus, Campylobacter jejuni, Campylobacter coli, Borrelia burgdorferi, Vibrio cholera, Vibrio parahaemolyticus, Legionella pneumophila, Listeria monocytogenes, Neisseria gonorrhoeae, Neisseria meningitidis, Burkholderia cepacia, Francisella tularensis, Kingella , and Moraxella.
3. The method of claim 2 , wherein the lung infection is caused by one or more of the following bacteria: Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Haemophilus influenzae, Burkholderia cepacia , and Moraxella.
4. The method of claim 1 , wherein the lung infection is caused by a Mycobacterium bacteria.
5. The method of claim 4 , wherein the lung infection is caused by one or more bacteria selected from the group consisting of Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium intracellulare , and Mycobacterium leprae.
6. The method of claim 1 , wherein about 20 mg of levofloxacin is administered to the lung.
7. The method of claim 6 , wherein about 100 mg of levofloxacin is administered to the lung.
8. The method of claim 7 , wherein about 125 mg of levofloxacin is administered to the lung.
9. The method of claim 8 , wherein about 150 mg of levofloxacin is administered to the lung.
10. The method of claim 1 , wherein the aerosol is administered to the lung in less than 10 minutes.
11. The method of claim 10 , wherein the aerosol is administered to the lung in less than 5 minutes.
12. The method of claim 11 , wherein the aerosol is administered to the lung in less than 3 minutes.
13. The method of claim 12 , wherein the aerosol is administered to the lung in less than 2 minutes.