pH-modulating biodegradable polymer and poly(glycerol sebacate)-augmented cell culture media
A pH-modulating poly(glycerol sebacate) composition includes poly(glycerol sebacate) and at least one pH-modulating agent associated with the poly(glycerol sebacate). A process of making a pH-modulating poly(glycerol sebacate) composition includes forming a poly(glycerol sebacate) by a water-mediated reaction from glycerol and sebacic acid and associating at least one pH-modulating agent with the poly(glycerol sebacate). A process of modulating a pH of a buffered aqueous solution includes placing a pH-modulating poly(glycerol sebacate) composition in a buffered aqueous solution. The pH-modulating agent is released into the buffered aqueous solution during degradation of the poly(glycerol sebacate) to reduce a decrease in pH of the buffered aqueous solution caused by degradation of the poly(glycerol sebacate).
1. A process of modulating a pH of a buffered aqueous solution, the process comprising placing a pH-modulating poly(glycerol sebacate) composition in a buffered aqueous solution, the pH-modulating poly(glycerol sebacate) composition comprising poly(glycerol sebacate) and at least one pH-modulating agent associated with the poly(glycerol sebacate), the pH-modulating agent being released into the buffered aqueous solution during degradation of the poly(glycerol sebacate) to reduce a decrease in pH of the buffered aqueous solution caused by degradation of the poly(glycerol sebacate).
2. The process of claim 1 , wherein the buffered aqueous solution has a pH in the range of 7.0 to 7.7 prior to placing the pH-modulating poly(glycerol sebacate) composition in the buffered aqueous solution.
3. The process of claim 1 , wherein the at least one pH-modulating agent is selected from the group consisting of an inorganic salt, an amino acid, and a protein.
4. The process of claim 1 , wherein the at least one pH-modulating agent is selected from the group consisting of arginine, histidine, and tyrosine.
5. The process of claim 1 , wherein the at least one pH-modulating agent is lysine.
6. The process of claim 1 , wherein the at least one pH-modulating agent is present in the pH-modulating poly(glycerol sebacate) composition in an amount, by weight, of about 5% or greater with respect to the weight of the pH-modulating poly(glycerol sebacate) composition.
7. The process of claim 1 , wherein the at least one pH-modulating agent is present in the pH-modulating poly(glycerol sebacate) composition in an amount, by weight, of about 10% or greater with respect to the weight of the pH-modulating poly(glycerol sebacate) composition.