Anti-neoplastic combinations and dosing regimens using CDK4/6 inhibitor compounds to treat Rb-positive tumors
This invention directed to methods for treating select RB-positive cancers and other Rb-positive abnormal cellular proliferative disorders using CDK4/6 inhibitors in specific dosing and combination or alternation regimes. In one aspect, treatments of select RB-positive cancers are disclosed using specific CDK4/6 inhibitors in combination or alternation with a Bruton's tyrosine kinase (BTK) inhibitor.
1. A method for the treatment of acute myeloid leukemia (AML) in a human in need thereof comprising administering an effective amount of Bruton's tyrosine kinase (BTK) inhibitor selected from ibrutinib and acalabrutinib in combination with a CDK 4/6 inhibitor compound of the structure
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the Bruton's tyrosine kinase (BTK) inhibitor is ibrutinib.
3. The method of claim 1 , wherein the Bruton's tyrosine kinase (BTK) inhibitor is acalabrutinib.
4. A method for the treatment of acute lymphoblastic leukemia (ALL) in a human in need thereof comprising administering an effective amount of Bruton's tyrosine kinase (BTK) inhibitor selected from ibrutinib and acalabrutinib in combination with a CDK 4/6 inhibitor compound of the structure
or a pharmaceutically acceptable salt thereof.
5. The method of claim 4 , wherein the Bruton's tyrosine kinase (BTK) inhibitor is ibrutinib.
6. The method of claim 4 , wherein the Bruton's tyrosine kinase (BTK) inhibitor is acalabrutinib.