Cannabinoid Dosing Regime for Acne
A method for treat acne comprising administering between 50 mg and 3000 mg of a topical liquid or gel composition comprising between 1% w/w and 15% w/w cannabinoid, wherein the cannabinoid is dissolved in the liquid or gel composition is described.
1 . A method for treating acne, comprising the administration of:
a) between 50 mg and 3000 mg of a topical liquid or gel composition comprising between 1% w/w and 15% w/w cannabinoid, wherein the cannabinoid is dissolved in the liquid or gel composition.
2 . The method of claim 1 , wherein the topical composition is administered to the skin between 1 and 5 times per day.
3 . The method of claim 1 , wherein the topical composition delivers between 20 mg and 400 mg of cannabinoid per administration.
4 . The method of claim 1 , wherein the total daily dose applied to the skin is between 20 mg and 2000 mg cannabinoid.
5 . The method of claim 1 wherein:
a) the topical composition comprises 2.5% w/w or 5% w/w cannabinoid; and/or
b) the regime delivers 37.5 mg, 75 mg or 150 mg of cannabinoid per day.
6 . The method of claim 1 , wherein the cannabinoid is delivered in a composition comprising: (i) a volatile solvent; and (ii) a residual solvent that is less volatile than (i).
7 . The method of claim 6 , wherein the volatile solvent is a non-polymeric siloxane.
8 . The method of claim 6 , wherein the volatile solvent is a combination of a non-polymeric siloxane and a C 2 -C 6 alcohol.
9 . The method of claim 8 , wherein the composition comprises 85-95% w/w siloxane and 1-10% wt/wt C 2 -C 6 alcohol.
10 . The method regime of claim 9 , wherein the siloxane has two or three silicon atoms per molecule.
11 . The method of claim 10 wherein the siloxane comprises hexamethyldisiloxane.
12 . The method of claim 6 , wherein the residual solvent is a compound from the list comprising: fatty acids, fatty acid alcohols, fatty alcohols, glycols, alkanes, ethers of any of these, and combinations thereof.
13 . The method of claim 12 , wherein the composition comprises 1-10% wt/wt of residual solvent.
14 . The method of claim 13 , wherein the residual solvent is a compound from the list comprising: alkyl polypropylene glycol, polyethylene glycol ether, oleyl alcohol, isostearyl alcohol, octyldodecyl alcohol, 2-hexyl decyl alcohol, isohexadecane.