Halogenated esters of cyclopropanated unsaturated fatty acids for use in the treatment of neurodegenerative diseases
The present disclosure describes novel PKC-ε activators chosen from halogenated esters of unsaturated fatty acids and derivatives thereof, including halogenated esters of both polyunsaturated and monounsaturated fatty acids and derivatives thereof. The disclosure further relates to compositions, kits, and methods for treatment using the halogenated esters.
1. A method for treating a neurodegenerative disorder comprising administering to a patient in need thereof an effective amount of at least one cyclopropanated esterified fatty acid containing an alkoxy group with at least one CF3 group in the ester portion, wherein the neurodegenerative disorder is selected from Alzheimer's Disease, Parkinson's Disease, Fragile X, Niemann-Pick C, and dementia and
wherein the at least one cycloproponated esterified fatty acid comprises a cyclopropanated version of 8-[2-(2-pentylcyclopropylmethyl)-cyclopropyl]-octanoic acid (DCPLA) containing an alkoxy group with at least one CF 3 group in the ester portion.
2. The method of claim 1 , wherein the cyclopropanated esterified fatty acid is chosen from
3. A method of improving at least one of memory and learning, comprising administering to a subject in need thereof an effective amount of at least one cyclopropanated esterified unsaturated fatty acid selected from the following molecules: