Transdermal drug delivery apparatus and methods
A transdermal drug delivery apparatus includes a receptacle having a housing and a microneedle assembly mounted to the housing. The apparatus includes a reservoir for being mounted to the receptacle. The reservoir has an interior for containing fluid for being supplied to the microneedle assembly. The apparatus is adapted so that, when the apparatus is assembled, the reservoir is configured to move relative to the microneedle assembly along a path from an outer position to an inner position. The reservoir is closer to the microneedle assembly in the inner position than in the outer position. In the outer position, the reservoir is out of fluid communication with the microneedle assembly, and in the inner position, the reservoir is in fluid communication with the microneedle assembly. The apparatus also includes a plurality of connector parts spaced apart from one another along the path.
1. A transdermal drug delivery apparatus comprising:
a receptacle comprising a housing and a microneedle assembly mounted to the housing;
a reservoir for being mounted to the receptacle, the reservoir having an interior for containing fluid for being supplied to the microneedle assembly, wherein
the apparatus is adapted so that, when the apparatus is assembled, the reservoir is configured to move relative to the microneedle assembly along a path from an outer position to an inner position,
the reservoir being closer to the microneedle assembly in the inner position than in the outer position,
in the outer position, the reservoir being out of fluid communication with the microneedle assembly, and
in the inner position, the reservoir being in fluid communication with the microneedle assembly;
a plurality of connector parts spaced apart from one another along the path, and configured for
releasably securing the reservoir in a first position, and
securing the reservoir in a second position;
a first force provider configured to provide a first force to force the microneedle assembly outwardly from the housing and against the skin of a user; and
a second force provider configured to provide a second force to cause at least some of the fluid to flow from the reservoir to the microneedle assembly.
2. The apparatus according to claim 1 , wherein the plurality of connector parts comprise snap-fit connector parts.
3. The apparatus according to claim 1 , further comprising a pushing mechanism for moving the reservoir from the outer position to the inner position.
4. The apparatus according to claim 3 , wherein the pushing mechanism comprises a pushbutton.
5. The apparatus according to claim 3 , wherein the pushing mechanism is an outer pushing mechanism, and the apparatus further comprises:
an inner pushing mechanism mounted to the outer pushing mechanism for being moved relative to the outer pushing mechanism; and
a force provider operatively associated with the inner pushing mechanism for moving the inner pushing mechanism relative to both the outer pushing mechanism and the reservoir for at least partially collapsing the reservoir.
6. The apparatus according to claim 5 , wherein the apparatus further comprises a latching mechanism for releasing the inner pushing mechanism in response to predetermined relative movement between the outer pushing mechanism and the housing.
7. The apparatus according to claim 1 , wherein the first force provider is compressed to provide the first force.
8. The apparatus according to claim 1 , wherein the second force provider is configured to provide the second force at least partially in response to the moving of the reservoir into fluid communication with the microneedle assembly.
9. The apparatus according to claim 1 , wherein:
the first force provider comprises a first spring; and
the first force is provided in response to the first spring being compressed.
10. The apparatus according to claim 9 , wherein:
the second force provider comprises a second spring; and
the second force is provided in response to the second spring expanding.
11. The apparatus of claim 10 , wherein the first spring is larger than the second spring.
12. The apparatus according to claim 1 , wherein the second force provider is configured to provide the second force in response to the pushing of a pushbutton of the apparatus.
13. The apparatus according to claim 1 , wherein the second force provider is configured to at least partially collapse the reservoir.
14. The apparatus according to claim 13 , wherein the second force provider is configured to provide the second force in response to an expanding second spring urging a pushing mechanism against the reservoir.
15. The apparatus according to claim 1 , wherein the first and second force providers are respectively configured so that the first force is greater than the second force.
16. The apparatus according to claim 1 , further comprising a fastener configured to fasten the housing to the skin of a user.
17. The apparatus according to claim 1 , wherein the microneedle assembly is movably mounted to the housing to allow relative movement between the microneedle assembly and the housing.
18. The apparatus according to claim 17 , wherein the microneedle assembly is movably mounted to the housing by at least one spring configured to force the microneedle assembly against the skin of a user.