IP Library › Patent Application 16261191
Patent Application
App. No. 16/261,191

CRYSTALLINE FORM OF y-AMINOBUTYRIC ACID ANALOG

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Patent No.
US None
App. No.
16/261,191
Abstract

A crystalline form of a γ-aminobutyric acid analog, and methods of preparing same, are provided.

Claims (9)

1 . Unsolvated crystalline 1-{[(α-isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid.

2 . The crystal of claim 1 corresponding to the representative X-ray powder diffraction pattern of FIG. 1 in an X-ray powder diffractogram using Cu Kα radiation.

3 . The crystal of claim 1 having an X-ray powder diffraction pattern comprising peaks at 7.0, 16.4 and 17.9±0.3 degrees 2Ξ in an X-ray powder diffractogram using Cu Kα radiation.

4 . The crystal of claim 3 further comprising peaks at 8.2, 10.5, 18.9, 20.9 and 23.3±0.3 degrees 2θ in an X-ray powder diffractogram using Cu Kα radiation.

5 . The crystal of claim 1 corresponding to the representative thermogravimetric analysis thermogram of FIG. 2 .

6 . The crystal of claim 1 having a differential scanning calorimetry thermogram comprising an exotherm with a maximum at 63±2° C., as determined by a differential scanning calorimetry at a scan rate of 5°C./minute.

7 . A method of treating restless legs syndrome comprising administering unsolvated crystalline 1-{[(α-isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid.

8 . A method of treating post herpetic neuralgia comprising administering unsolvated crystalline 1-{[(α-isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid.

9 . A pharmaceutical composition comprising the unsolvated crystalline 1-{[(α-isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid.