WOVEN GRAFT COMPOSITE WITH VARIED DENSITY
The disclosure describes textiles for endovascular and other medical applications having a low-profile and varying density. The textiles are woven and are formed of a non-uniform construction. The resulting textiles have a low profile and areas of targeted density to enhance ingrowth of regenerative tissue.
1 . A woven implantable textile comprising:
a continuous length of woven textile having a first region and a second region of a common face;
the first woven region having a first ends per inch in a warp and a first picks per inch in a weft, defining a first density;
the second woven region having a second ends per inch in the warp and a second picks per inch in the weft, defining a second density different from the first density;
a bioresorbable coating overlying the first and second woven regions to form a composite textile,
wherein the weave construction of the first woven region and the second woven region are the same.
2 . The textile of claim 1 :
wherein the first ends per inch and the second ends per inch are the same; and
wherein the first picks per inch and the second picks per inch are different.
3 . The textile of claim 1 , further comprising a gradient of picks in a transition region between the first woven region and the second woven region.
4 . The textile of claim 1 , wherein the textile is less than 100 micrometers thick.
5 . The textile of claim 1 , wherein the weave construction is a plain weave, a twill weave, a warp rib weave, a weft rib weave, a leno weave, deflected weft weave, or a mock leno weave.
6 . The textile of claim 5 , wherein the weave construction is a weft rib weave.
7 . The textile of claim 1 , wherein the textile includes a polyethylene terephthalate yarn in the warp.
8 . The textile of claim 1 , wherein the polyethylene terephthalate yarn denier is between 15 denier and 50 denier.
9 . The textile of claim 1 , wherein the textile includes a resorbable yarn in the weft.
10 . The textile of claim 1 , wherein the textile exhibits a water permeability of less than 500 milliliters/minute/centimeter 2 .
11 . The textile of claim 1 , wherein the textile exhibits a water permeability of less than 5 milliliters/minute/centimeter 2 .
12 . The textile of claim 1 , wherein the textile exhibits an average pore size of 10 micrometers to 800 micrometers in at least one region.
13 . The textile of claim 1 , wherein the bioresorbable coating is selected from the group consisting of polycaprolactone (PCL), polylactic acid (PLA), polyglycolic acid (PGA), poly(lactic-co-glycolic acid) (PLGA), poly(glycerol sebacate) (PGS), Lysine-poly(glycerol sebacate) (KPGS), poly(glycerol sebacate urethane) (PGSU), amino-acid incorporated PGS, and combinations thereof.
14 . A woven implantable textile comprising:
a continuous length of woven textile having a first region and a second region of a common face;
the first woven region formed from a first woven construction;
the second woven region formed from a second woven construction;
wherein the weave construction of the first woven region is different from the weave construction of the second woven region.
15 . The textile of claim 14 :
wherein the first woven construction is selected from the group consisting of a plain weave, a twill weave, a warp rib weave, a weft rib weave, a leno weave, and a mock leno weave; and
wherein the second woven construction is selected from the group consisting of a plain weave, a twill weave, a warp rib weave, a weft rib weave, a leno weave, a deflected weft weave and a mock leno weave.
16 . The textile of claim 15 , wherein the first woven construction is a plain weave and the second woven construction is a weft rib weave.
17 . The textile of claim 14 , further comprising a bioresorbable coating overlying the textile, the coating selected from the group consisting of polycaprolactone (PCL), polylactic acid (PLA), polyglycolic acid (PGA), poly(lactic-co-glycolic acid) (PLGA), poly(glycerol sebacate) (PGS), Lysine-poly(glycerol sebacate) (KPGS), poly(glycerol sebacate urethane) (PGSU), amino-acid incorporated PGS, and combinations thereof, thereby forming a composite textile.
18 . The textile of claim 17 , wherein the composite textile exhibits a water permeability of less than 5 milliliters/minute/centimeter 2 .
19 . The textile of claim 14 , further comprising a coating overlying the textile to form a composite textile, the composite textile being less than 100 micrometers thick and having a water permeability of less than 5 milliliters/minute/centimeter 2 .
20 . The textile of claim 14 , wherein the textile exhibits an average pore size of 10 micrometers to 800 micrometers in at least one woven region.
21 . The textile of claim 14 , wherein the textile includes a polyethylene terephthalate yarn in the warp.
22 . The textile of claim 14 , wherein the polyethylene terephthalate yarn denier is between 15 denier and 50 denier.
23 . The textile of claim 14 , wherein the textile includes a resorbable yarn in the weft.