IP Library › Granted Patent US 11,090,341
Granted Patent B2
US 11,090,341 · App. 16/268,745 · Granted Aug 17, 2021

Compositions and methods for treating cancer and immune disorders using

Inventors: Brian Goodman (Jamaica Plain, MA); Baundauna Bose (Cambridge, MA); Christopher J. H. Davitt (Boston, MA); Maria Sizova (Roslindale, MA); Sofia M. R. Carlton (Jamaica Plain, MA); Andrea Itano (Arlington, MA); Holly Ponichtera (Cambridge, MA); Taylor A. Cormack (Dedham, MA); Kritika Ramani (Cambridge, MA)
Assignee: Evelo Biosciences, Inc.
A61K35/74A61K45/06A61P1/16A61P3/10A61P17/06A61P19/02A61P35/00A61P37/06
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Quick Facts
Patent No.
US 11,090,341
App. No.
16/268,745
Granted
Aug 17, 2021
Kind
B2
Abstract

Provided herein are methods and compositions related to Veillonella bacteria useful as therapeutic agents.

Claims (12)

1. A pharmaceutical composition formulated for oral administration comprising bacteria comprising Veillonella parvula Strain B (ATCC Accession Number PTA-125691) and a pharmaceutically acceptable carrier within an enteric coating.

2. The pharmaceutical composition of claim 1 , wherein at least 50% of the bacteria in the pharmaceutical composition are Veillonella parvula Strain B (ATCC Accession Number PTA-125691).

3. The pharmaceutical composition of claim 2 , wherein at least 95% of the bacteria in the pharmaceutical composition are Veillonella parvula Strain B (ATCC Accession Number PTA-125691).

4. The pharmaceutical composition of claim 1 , comprising at least 1×10 6 colony forming units (CFUs) of Veillonella parvula Strain B (ATCC Accession Number PTA-125691).

5. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition comprises live bacteria.

6. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition comprises killed bacteria.

7. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition comprises irradiated bacteria.

8. The pharmaceutical composition of claim 7 , wherein the pharmaceutical composition comprises gamma irradiated bacteria.

9. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is formulated in an enteric coated tablet.

10. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is formulated in an enteric coated capsule.

11. The pharmaceutical composition of claim 1 , wherein the enteric coating is a coating for duodenal release at a pH of about 5.5-6.2.

12. The pharmaceutical composition of claim 1 , wherein the Veillonella parvula Strain B (ATCC Accession Number PTA-125691) is freeze-dried.

Assignments (5)
SECURITY INTEREST Recorded Jul 14, 2023
From: EVELO BIOSCIENCES, INC.
To: HORIZON TECHNOLOGY FINANCE CORPORATION
Reel/Frame 064274/0354 →
CORRECTIVE ASSIGNMENT TO CORRECT THE THE ASSIGNMENT FILING DATE TO FEBRUARY 6, 2019 PREVIOUSLY RECORDED AT REEL: 049700 FRAME: 0878. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Oct 12, 2021
From: GOODMAN, BRIAN; BOSE, BAUNDAUNA; DAVITT, CHRISTOPHER J.H.; SIZOVA, MARIA; CARLTON, SOFIA M.R.; ITANO, ANDREA; PONICHTERA, HOLLY; CORMACK, TAYLOR A.; RAMANI, KRITIKA
To: EVELO BIOSCIENCES, INC.
Reel/Frame 057772/0258 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 20, 2021
From: RAMANI, KRITIKA
To: EVELO BIOSCIENCES, INC.
Reel/Frame 056302/0725 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 9, 2019
From: GOODMAN, BRIAN; BOSE, BAUNDAUNA; DAVITT, CHRISTOPHER J. H.; SIZOVA, MARIA; CARLTON, SOFIA M. R.; ITANO, ANDREA; PONICHTERA, HOLLY; CORMACK, TAYLOR A.
To: EVELO BIOSCIENCES, INC.
Reel/Frame 049697/0373 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 9, 2019
From: GOODMAN, BRIAN; BOSE, BAUNDAUNA; DAVITT, CHRISTOPHER J.H.; SIZOVA, MARIA; CARLTON, SOFIA M.R.; ITANO, ANDREA; PONICHTERA, HOLLY; CORMACK, TAYLOR A.
To: EVELO BIOSCIENCES, INC.
Reel/Frame 049700/0878 →
Continuity (4)
Provisional Application 62703269 · Jul 25, 2018
Provisional Application 62666944 · May 4, 2018
Provisional Application 62626789 · Feb 6, 2018
Related Publication 20190350987A1 · Nov 21, 2019