IP Library Granted Patent US 11,147,570
Granted Patent B2
US 11,147,570 · App. 16/269,229 · Granted Oct 19, 2021

Method for reducing biofilm formation

Inventors: Paul Mikus (Coto de Caza, CA); Scott Isola (Deer Park, NY); Dan Voic (Cedar Grove, NJ); Scott Ludecker (Mount Sinai, NY); Alexander Darian (Brightwaters, NY)
Assignee: MISONIX, INCORPORATED
A61B17/22004A61B2217/005A61M1/85A61M2205/058
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Quick Facts
Patent No.
US 11,147,570
App. No.
16/269,229
Granted
Oct 19, 2021
Kind
B2
Abstract

A two phase method for reducing the formation of biofilm includes an evacuation of ambient air from a region about the surgical or treatment site, to extract airborne or aerosolized bacteria ejected from the site by the treatment. The extracted bacteria are prevented from settling back onto the cleansed tissue surface, thus at least reducing colonial bacteriological growth and concomitantly exuded biofilm material. A second phase involves the attachment of one or more ultrasonic transducers to the patient over or near a surgical treatment site after the surgery is terminated. Each applied ultrasonic transducer is used to vibrate the patient's tissues at the treatment site to disrupt biofilm formation.

Claims (8)

1. A medical therapeutic method comprising:

removing necrotic tissue and undesired organic material from a surgical site on a patient;

after the removal of all discernible necrotic tissue and undesirable organic material from the surgical site and while the surgical site is free of discernible bacteria, placing at least one ultrasonic transducer on the patient at least proximate the surgical site; and

after the placing of said transducer and while said transducer is in effective vibration-transmitting contact with the patient, conducting an electrical energization waveform of an ultrasonic frequency to said transducer at least intermittently during a period of approximately one day or longer, said waveform having frequency, amplitude and duration to effectively reduce biofilm formation on the patient at the surgical site and thereby facilitate a healing of the patient's tissue at the surgical site.

2. The method defined in claim 1 wherein the placing of said transducer includes removably attaching said transducer to the patient.

3. The method defined in claim 2 wherein the placing of said transducer includes removably attaching said transducer atop tissues at the surgical site.

4. The method defined in claim 2 wherein said transducer is affixed to a carrier pad, the placing of said transducer on the patient including attaching said pad to the patient.

5. The method defined in claim 1 wherein the removing of necrotic tissues includes operating an ultrasonic debrider instrument at a first energy setting, further comprising utilizing said instrument at a lower second energy setting to pre-condition the tissues at the surgical site for disrupting adherence or starting the formation of biofilm.

Assignments (10)
RELEASE OF SECURITY INTEREST Recorded Aug 4, 2025
From: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
To: MISONIX OPCO, LLC
Reel/Frame 072338/0395 →
SECURITY INTEREST Recorded Aug 1, 2025
From: MISONIX, LLC
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 072298/0866 →
MERGER AND CHANGE OF NAME Recorded Nov 28, 2022
From: MISONIX INCORPORATED; OYSTER MERGER SUB II, LLC
To: MISONIX, LLC
Reel/Frame 061891/0762 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 8, 2022
From: MIKUS, PAUL; ISOLA, SCOTT; VOIC, DAN; LUDECKER, SCOTT; DARIAN, ALEXANDER
To: MISONIX INCORPORATED
Reel/Frame 061690/0592 →
MERGER AND CHANGE OF NAME Recorded Sep 14, 2022
From: OYSTER OPCO MERGER SUB, LLC; MISONIX OPCO, INC.
To: MISONIX OPCO, LLC
Reel/Frame 061433/0736 →
RELEASE OF SECURITY INTEREST Recorded May 31, 2022
From: SWK FUNDING, LLC, AS COLLATERAL AGENT
To: MISONIX OPCO, INC.
Reel/Frame 060220/0792 →
RELEASE OF SECURITY INTEREST Recorded May 31, 2022
From: SILICON VALLEY BANK
To: MISONIX OPCO, INC.
Reel/Frame 060220/0773 →
SECURITY INTEREST Recorded Nov 11, 2021
From: MISONIX OPCO, LLC
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 058809/0950 →
INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Mar 16, 2020
From: MISONIX OPCO, INC.
To: SWK FUNDING LLC
Reel/Frame 052167/0275 →
INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Dec 30, 2019
From: MISONIX OPCO, INC.
To: SILICON VALLEY BANK
Reel/Frame 051447/0334 →