IP Library Patent Application 16272817
Patent Application
App. No. 16/272,817

PROCESS TO EXTRACT AND PURIFY DELTA-9-TETRAHYDROCANNABINOL

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Quick Facts
Patent No.
US None
App. No.
16/272,817
Abstract

Δ 9 -THC carboxylic acid is extracted from cannabis flowers using a first organic solvent, then separated using a second aqueous solvent. Δ 9 -THC carboxylic acid is converted to Δ 9 -THC carboxylic salt before being extracted by a third organic solvent and converted back to Δ 9 -THC carboxylic acid. Using a solvent swap, Δ 9 -THC carboxylic acid is decarboxylated and extracted again with an organic solvent prior to purification to give Δ 9 -THC.

Claims (32)

1 . A method of producing Δ 9 -THC consisting essentially of:

extracting Δ 9 -THC carboxylic acid from cannabis flowers using heptane to obtain a heptane extract;

filtering the heptane extract to remove solid plant matter;

separating the Δ 9 -THC carboxylic acid from the heptane extract by contacting the heptane extract with sodium chloride water adjusted to a pH range of 13.2 to 13.4 using an inorganic base to form a liquid mixture;

stirring the liquid mixture; and

leaving the liquid mixture to settle;

wherein the liquid mixture forms three layers consisting of a first organic layer, a second oily layer, and third aqueous layer; and

separating out the oily layer from the other two layers by a separatory funnel.

2 . The method of claim 1 , further consisting essentially of suspending the oily layer in an aqueous solvent containing sodium chloride and an inorganic base to adjust the aqueous solvent to a pH of 13.2 to 13.4 to convert Δ 9 -THC carboxylic acid to Δ 9 -THC carboxylic salt.

3 . The method of claim 2 , further consisting essentially of extracting Δ 9 -THC carboxylic salt with an organic solvent.

4 . The method of claim 3 , wherein the organic solvent is tert-butyl methyl ether.

5 . The method of claim 3 , further consisting essentially of converting the Δ 9 -THC carboxylic acid salt in the organic solvent back to Δ 9 -THC carboxylic acid by adding an aqueous solvent containing sodium chloride and an inorganic base to adjust the aqueous solvent to a pH of 13.2 to 13.4 and a strong inorganic acid into the Δ 9 -THC carboxylic salt in organic solvent mixture.

6 . The method of claim 5 , further consisting essentially of:

washing the resulting mixture with a sodium chloride water solution to form an organic solvent layer and an aqueous layer; and

separating the organic solvent layer from the aqueous layer,

wherein the organic solvent layer comprises Δ 9 -THC carboxylic acid in water and organic solvent.

7 . The method of claim 6 , further consisting essentially of:

removing water from the Δ 9 -THC carboxylic acid in water and organic solvent mixture using Na 2 SO 4 ;

removing the organic solvent using vacuum to give a crude solid containing Δ 9 -THC carboxylic acid;

dissolving the solid in pentane;

treating the crude solid containing Δ 9 -THC carboxylic acid dissolved in pentane with active carbon to remove non-THC cannabinoids;

removing the pentane using vacuum; and

filtering to obtain Δ 9 -THC carboxylic acid solid.

8 . The method of claim 7 , further consisting essentially of:

dissolving Δ 9 -THC carboxylic acid solid into an alcohol and adding the mixture into boiling water;

heating the mixture to between 80° C. and 100° C. for at least 40 minutes; and

cooling the mixture to room temperature and adding a sodium chloride solution into the mixture;

wherein the Δ 9 -THC carboxylic acid is decarboxylated to convert Δ 9 -THC carboxylic acid to Δ 9 -THC.

9 . The method of claim 8 , wherein the alcohol is ethanol, isopropyl alcohol, propyl alcohol, or butyl alcohol.

10 . The method of claim 8 , further consisting essentially of extracting Δ 9 -THC using n-pentane 1 to 3 times.

11 . The method of claim 10 , further consisting essentially of purifying Δ 9 -THC by removing water using Na 2 SO 4 and removing n-pentane by vacuum.

12 . The method of claim 11 , further consisting essentially of combining purified Δ 9 -THC with a pharmaceutically acceptable carrier.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 16, 2023
From: AXIM BIOTECHNOLOGIES, INC
To: APIRX PHARMACEUTICAL USA, LLC
Reel/Frame 063653/0719 →