Heterocyclic compounds as kinase inhibitors
Heterocyclic compounds of Formula (J) as CDK4 or CDK6 or other CDK inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.
1. A compound, or pharmaceutically acceptable a salt thereof, wherein the compound is selected from the group consisting of
2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:
3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:
4. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:
5. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:
6. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
7. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
8. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
9. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
10. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
11. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
12. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
13. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
14. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
15. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
16. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
17. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
18. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
19. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
20. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
21. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
22. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
23. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
24. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
25. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
26. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
27. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
28. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
29. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is
30. The compound of claim 6 , wherein the compound is
31. The compound of claim 7 , wherein the compound is
32. The compound of claim 8 , wherein the compound is
33. The compound of claim 9 , wherein the compound is
34. The compound of claim 10 , wherein the compound is
35. The compound of claim 11 , wherein the compound is
36. The compound of claim 12 , wherein the compound is
37. The compound of claim 13 , wherein the compound is
38. The compound of claim 19 , wherein the compound is
39. The compound of claim 15 , wherein the compound is
40. The compound of claim 16 , wherein the compound is
41. The compound of claim 17 , wherein the compound is
42. The compound of claim 18 , wherein the compound is
43. The compound of claim 19 , wherein the compound is
44. The compound of claim 20 , wherein the compound is
45. The compound of claim 21 , wherein the compound is
46. The compound of claim 22 , wherein the compound is
47. The compound of claim 23 , wherein the compound is
48. The compound of claim 24 , wherein the compound is
49. The compound of claim 25 , wherein the compound is
50. The compound of claim 26 , wherein the compound is
51. The compound of claim 27 , wherein the compound is
52. The compound of claim 28 , wherein the compound is
53. The compound of claim 29 , wherein the compound is
54. A pharmaceutical composition comprising a compound of claim 1 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
55. A pharmaceutical composition comprising a compound of claim 2 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
56. A pharmaceutical composition comprising a compound of claim 3 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
57. A pharmaceutical composition comprising a compound of claim 4 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
58. A pharmaceutical composition comprising a compound of claim 5 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
59. A pharmaceutical composition comprising a compound of claim 6 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
60. A pharmaceutical composition comprising a compound of claim 7 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
61. A pharmaceutical composition comprising a compound of claim 8 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
62. A pharmaceutical composition comprising a compound of claim 9 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
63. A pharmaceutical composition comprising a compound of claim 10 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
64. A pharmaceutical composition comprising a compound of claim 11 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
65. A pharmaceutical composition comprising a compound of claim 12 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
66. A pharmaceutical composition comprising a compound of claim 13 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
67. A pharmaceutical composition comprising a compound of claim 14 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
68. A pharmaceutical composition comprising a compound of claim 15 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
69. A pharmaceutical composition comprising a compound of claim 16 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
70. A pharmaceutical composition comprising a compound of claim 17 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
71. A pharmaceutical composition comprising a compound of claim 18 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
72. A pharmaceutical composition comprising a compound of claim 19 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
73. A pharmaceutical composition comprising a compound of claim 20 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
74. A pharmaceutical composition comprising a compound of claim 21 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
75. A pharmaceutical composition comprising a compound of claim 22 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
76. A pharmaceutical composition comprising a compound of claim 23 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
77. A pharmaceutical composition comprising a compound of claim 24 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
78. A pharmaceutical composition comprising a compound of claim 25 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
79. A pharmaceutical composition comprising a compound of claim 26 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
80. A pharmaceutical composition comprising a compound of claim 27 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
81. A pharmaceutical composition comprising a compound of claim 28 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
82. A pharmaceutical composition comprising a compound of claim 29 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
83. A pharmaceutical composition comprising a compound of claim 30 and a pharmaceutically acceptable carrier.
84. A pharmaceutical composition comprising a compound of claim 31 and a pharmaceutically acceptable carrier.
85. A pharmaceutical composition comprising a compound of claim 32 and a pharmaceutically acceptable carrier.
86. A pharmaceutical composition comprising a compound of claim 33 and a pharmaceutically acceptable carrier.
87. A pharmaceutical composition comprising a compound of claim 34 and a pharmaceutically acceptable carrier.
88. A pharmaceutical composition comprising a compound of claim 35 and a pharmaceutically acceptable carrier.
89. A pharmaceutical composition comprising a compound of claim 36 and a pharmaceutically acceptable carrier.
90. A pharmaceutical composition comprising a compound of claim 37 and a pharmaceutically acceptable carrier.
91. A pharmaceutical composition comprising a compound of claim 38 and a pharmaceutically acceptable carrier.
92. A pharmaceutical composition comprising a compound of claim 39 and a pharmaceutically acceptable carrier.
93. A pharmaceutical composition comprising a compound of claim 40 and a pharmaceutically acceptable carrier.
94. A pharmaceutical composition comprising a compound of claim 41 and a pharmaceutically acceptable carrier.
95. A pharmaceutical composition comprising a compound of claim 42 and a pharmaceutically acceptable carrier.
96. A pharmaceutical composition comprising a compound of claim 43 and a pharmaceutically acceptable carrier.
97. A pharmaceutical composition comprising a compound of claim 44 and a pharmaceutically acceptable carrier.
98. A pharmaceutical composition comprising a compound of claim 45 and a pharmaceutically acceptable carrier.
99. A pharmaceutical composition comprising a compound of claim 46 and a pharmaceutically acceptable carrier.
100. A pharmaceutical composition comprising a compound of claim 47 and a pharmaceutically acceptable carrier.
101. A pharmaceutical composition comprising a compound of claim 48 and a pharmaceutically acceptable carrier.
102. A pharmaceutical composition comprising a compound of claim 49 and a pharmaceutically acceptable carrier.
103. A pharmaceutical composition comprising a compound of claim 50 and a pharmaceutically acceptable carrier.
104. A pharmaceutical composition comprising a compound of claim 51 and a pharmaceutically acceptable carrier.
105. A pharmaceutical composition comprising a compound of claim 52 and a pharmaceutically acceptable carrier.
106. A pharmaceutical composition comprising a compound of claim 53 and a pharmaceutically acceptable carrier.