Isolated placental stem cell recruiting factors
Described herein are compositions and methods of using placental stem cell recruiting factors, more specifically, isolated placental stem cell recruiting factors. In one embodiment, isolated placental stem cell recruiting factors are delivered to a site such as a diseased or injured organ and/or body part in an amount sufficient to recruit stem cells to the site.
1. A composition comprising
a localization agent;
isolated placental stem cell recruiting factors in an amount sufficient to recruit stem cells to a diseased or injured organ or body part in vivo; and
modified placental tissue, wherein said modified placental tissue comprises amnion, chorion, intermediate layer, or a combination thereof, and wherein said modified placental tissue is not acellular.
2. The composition of claim 1 , wherein said modified placental tissue is a modified tissue graft.
3. The composition of claim 1 , wherein said modified placental tissue is micronized.
4. The composition of claim 1 , wherein said composition is provided in an aqueous solution.
5. The composition of claim 1 , wherein said composition is provided in an injectable formulation.
6. The composition of claim 1 , wherein said localization agent is a thixotropic agent or a phase changing agent.
7. The composition of claim 6 , wherein said thixotropic agent is selected from the group consisting of hyaluronic acid, collagen, thrombin gels, fibrin gels and fibrin glues.
8. The composition of claim 6 , wherein said phase changing agent is a gel forming agent.
9. The composition of claim 8 , wherein said gel forming agent is a copolymer or tripolymer of oxyethylene and oxypropylene units.
10. The composition of claim 1 , wherein said localization agent is selected from the group consisting of a hydrogel, a polymer, and a collagen gel.
11. A method for preparing a composition according to claim 1 .