IP Library › Granted Patent US 10,875,837
Granted Patent B2
US 10,875,837 · App. 16/279,904 · Granted Dec 29, 2020

Inhibitors of the fibroblast growth factor receptor

Inventors: Neil Bifulco, Jr. (Sudbury, MA); Lucian V. DiPietro (Gloucester, MA); Brian L. Hodous (Arlington, MA); Chandrasekhar V. Miduturu (Cambridge, MA)
Assignee: BLUEPRINT MEDICINES CORPORATION
C07D401/04C07D235/30C07D239/84C07D401/12C07D403/12C07D403/14C07D405/12C07D409/12C07D471/04C07D475/00
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Quick Facts
Patent No.
US 10,875,837
App. No.
16/279,904
Granted
Dec 29, 2020
Kind
B2
Abstract

Described herein are inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

Claims (8)

1. A compound having the structure:

or a pharmaceutically acceptable salt thereof.

2. A compound having the structure:

or a pharmaceutically acceptable salt thereof.

3. The compound of claim 1 , wherein the compound is represented by:

4. A pharmaceutically acceptable salt of the compound of claim 1 .

5. The compound of claim 2 , wherein the compound is represented by:

6. A pharmaceutically acceptable salt of the compound of claim 2 .

Assignments (3)
RELEASE OF SECURITY INTEREST (REEL/FRAME NUMBER 060616/0923) Recorded Jul 23, 2025
From: TAO TALENTS, LLC
To: BLUEPRINT MEDICINES CORPORATION
Reel/Frame 072193/0847 →
SECURITY INTEREST Recorded Jul 8, 2022
From: BLUEPRINT MEDICINES CORPORATION
To: TAO TALENTS, LLC
Reel/Frame 060616/0923 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 19, 2019
From: DIPIETRO, LUCIAN V.; HODOUS, BRIAN L.; MIDUTURU, CHANDRASEKHAR V.; BIFULCO, NEIL, JR
To: BLUEPRINT MEDICINES CORPORATION
Reel/Frame 048377/0378 →
Continuity (5)
Continuation 15222523 · Jul 28, 2016
Continuation 14521909 · Oct 23, 2014
Provisional Application 61927782 · Jan 15, 2014
Provisional Application 61895472 · Oct 25, 2013
Related Publication 20200109127A1 · Apr 9, 2020
Cited By (1)
US 12,205,625