IP Library Granted Patent US 11,079,371
Granted Patent B2
US 11,079,371 · App. 16/280,635 · Granted Aug 3, 2021

Chemical sensors with non-covalent surface modification of graphene

Inventors: Xue Zhen (Minneapolis, MN); Philippe Pierre Joseph Buhlmann (Minneapolis, MN); Steven J. Koester (Edina, MN); Yao Zhang (Minneapolis, MN); Justin Theodore Nelson (Minneapolis, MN)
Assignees: Boston Scientific Scimed, Inc.; REGENTS OF THE UNIVERSITY OF MINNESOTA
G01N33/5308G01N27/125G01N27/227A61B5/082G01N27/4146
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Quick Facts
Patent No.
US 11,079,371
App. No.
16/280,635
Granted
Aug 3, 2021
Kind
B2
Abstract

Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included. The medical device can include a graphene varactor. The graphene varactor can include a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through π-π stacking interactions. The self-assembled monolayer can provide a Langmuir theta value of at least 0.9. The self-assembled monolayer can include polycyclic aromatic hydrocarbons, tetraphenylporphyrins or derivatives thereof, metallotetraphenylporphyrins, or aromatic cyclodextrins. Other embodiments are also included herein.

Claims (11)

1. A medical device comprising:

a graphene varactor comprising:

a graphene layer;

a self-assembled monolayer disposed on an outer surface of the graphene layer through π-π stacking interactions; and

wherein the self-assembled monolayer provides a Langmuir theta value of at least 0.9;

wherein the self-assembled monolayer comprises at least one metallotetraphenylporphyrin compound having the formula

wherein M is any metal atom comprising aluminum, calcium, magnesium, manganese, iron, cobalt, nickel, zinc, ruthenium, palladium, or derivatives thereof; where n can be any integer from 1 to 5; m can be 1 or 2; R 1 through R 8 comprise —H; —X, where X is any halogen atom; —R 9 ; —R 10 OH; —R 11 COOH; —R 12 COOR 13 ; —R 14 OR 15 ; —R 16 COH; —R 17 COR 18 ; —R 19 NH 3 + ; —R 20 NH 2 ; —R 21 NR 22 ; —R 23 NR 24 R 25+ ; —R 26 X or —R 27 COX, where X is any halogen atom; —R 28 SH or any combination thereof; and R 9 , through R 28 comprise any linear or branched C 1 -C 12 alkyl, C 1 -C 12 alkenyl, C 1 -C 12 alkynyl, or any combination thereof, or can be absent such that the remaining portion of the functional group is covalently bound directly to one or more carbon atoms of the base aromatic ring structure.

2. The medical device of claim 1 , comprising a plurality of graphene varactors configured in an array on the medical device.

3. The medical device of claim 1 , wherein the self-assembled monolayer provides a Langmuir theta value of at least 0.98.

4. The medical device of claim 1 , wherein the self-assembled monolayer provides coverage over the outer surface of the graphene layer from 50% to 150% by surface area.

5. The medical device of claim 1 , wherein the self-assembled monolayer provides coverage over the outer surface of the graphene layer from 99% to 120% by surface area.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 29, 2025
From: BOSTON SCIENTIFIC SCIMED, INC.
To: REGENTS OF THE UNIVERSITY OF MINNESOTA
Reel/Frame 072407/0410 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 11, 2020
From: ZHANG, YAO
To: REGENTS OF THE UNIVERSITY OF MINNESOTA
Reel/Frame 053453/0744 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 22, 2019
From: KOESTER, STEVEN J.
To: REGENTS OF THE UNIVERSITY OF MINNESOTA
Reel/Frame 050787/0271 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 25, 2019
From: ZHEN, XUE; NELSON, JUSTIN THEODORE
To: BOSTON SCIENTIFIC SCIMED, INC.
Reel/Frame 049864/0262 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 23, 2019
From: BUHLMANN, PHILIPPE PIERRE JOSEPH
To: REGENTS OF THE UNIVERSITY OF MINNESOTA
Reel/Frame 049836/0703 →
Cited By (3)
US 12,523,626 US 12,604,506 US 12,613,212